| Literature DB >> 10201821 |
S E de Laszlo1, C Hacker, B Li, D Kim, M MacCoss, N Mantlo, J V Pivnichny, L Colwell, G E Koch, M A Cascieri, W K Hagmann.
Abstract
The SAR of 2-pyridyl-3,5-diaryl pyrroles, ligands of the human glucagon receptor and inhibitors of p38 kinase, were investigated. This effort resulted in the identification of 2-(4-pyridyl)-5-(4-chlorophenyl)-3-(5-bromo-2-propyloxyphenyl)pyrr ole 49 (L-168,049), a potent (Kb = 25 nM), selective antagonist of glucagon.Entities:
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Year: 1999 PMID： 10201821 DOI： 10.1016/s0960-894x(99)00081-5
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823