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Literature DB >> 10200241

Tossing monkey wrenches into the clock: new ways of treating cancer.

J A Lees¹, R A Weinberg.

Abstract

Entities: Disease

Mesh：

Substances：

Year: 1999 PMID： 10200241 PMCID： PMC33556 DOI： 10.1073/pnas.96.8.4221

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

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18 in total

1. Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists.

Authors: Y N Chen; S K Sharma; T M Ramsey; L Jiang; M S Martin; K Baker; P D Adams; K W Bair; W G Kaelin
Journal: Proc Natl Acad Sci U S A Date: 1999-04-13 Impact factor: 11.205

2. A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F.

Authors: K Helin; J A Lees; M Vidal; N Dyson; E Harlow; A Fattaey
Journal: Cell Date: 1992-07-24 Impact factor: 41.582

Review 3. The regulation of E2F by pRB-family proteins.

Authors: N Dyson
Journal: Genes Dev Date: 1998-08-01 Impact factor: 11.361

4. Transcriptional repression. The cancer-chromatin connection.

Authors: R A DePinho
Journal: Nature Date: 1998-02-05 Impact factor: 49.962

Review 5. The restriction point and control of cell proliferation.

Authors: M D Planas-Silva; R A Weinberg
Journal: Curr Opin Cell Biol Date: 1997-12 Impact factor: 8.382

Review 6. Viewpoint: putting the cell cycle in order.

Authors: K Nasmyth
Journal: Science Date: 1996-12-06 Impact factor: 47.728

7. p53 and E2F-1 cooperate to mediate apoptosis.

Authors: X Wu; A J Levine
Journal: Proc Natl Acad Sci U S A Date: 1994-04-26 Impact factor: 11.205

8. Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos.

Authors: K Y Tsai; Y Hu; K F Macleod; D Crowley; L Yamasaki; T Jacks
Journal: Mol Cell Date: 1998-09 Impact factor: 17.970

Tossing monkey wrenches into the clock: new ways of treating cancer.

1. Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists.

2. A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F.

Review 3. The regulation of E2F by pRB-family proteins.

4. Transcriptional repression. The cancer-chromatin connection.

Review 5. The restriction point and control of cell proliferation.

Review 6. Viewpoint: putting the cell cycle in order.

7. p53 and E2F-1 cooperate to mediate apoptosis.

8. Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos.

9. The transcription factor E2F-1 mediates the autoregulation of RB gene expression.

10. Expression of transcription factor E2F1 induces quiescent cells to enter S phase.

1. Defining a role for sphingosine kinase 1 in p53-dependent tumors.

Review 2. Insights on Structural Characteristics and Ligand Binding Mechanisms of CDK2.