Literature DB >> 10198776

Regulation of bile acid biosynthesis.

Z R Vlahcevic1, W M Pandak, R T Stravitz.   

Abstract

This article provides a review of the pathways through which cholesterol is degraded to bile acids. Regulation of key enzymes in the bile acid biosynthestic pathways is discussed. The important role of these pathways in the maintenance of cholesterol homeostasis and the possible therapeutic implications for the treatment of hypercholesterolemia are emphasized.

Entities:  

Mesh：

Substances：

Year:  1999        PMID： 10198776     DOI： 10.1016/s0889-8553(05)70041-8

Source DB:  PubMed          Journal:  Gastroenterol Clin North Am        ISSN： 0889-8553            Impact factor:   3.806


  28 in total

1.  New horizons in the regulation of bile acid and lipid homeostasis: critical role of the nuclear receptor FXR as an intracellular bile acid sensor.

Authors:  M Arrese; S J Karpen
Journal:  Gut       Date:  2001-10       Impact factor: 23.059

2.  Inappropriate ileal conservation of bile acids in cholestatic liver disease: homeostasis gone awry.

Authors:  A F Hofmann
Journal:  Gut       Date:  2003-09       Impact factor: 23.059

3.  Adaptive regulation of the ileal apical sodium dependent bile acid transporter (ASBT) in patients with obstructive cholestasis.

Authors:  P Hruz; C Zimmermann; H Gutmann; L Degen; U Beuers; L Terracciano; J Drewe; C Beglinger
Journal:  Gut       Date:  2005-09-08       Impact factor: 23.059

4.  Suppression of bile acid synthesis by thyroid hormone in primary human hepatocytes.

Authors:  Ewa Cristine Siljevik Ellis
Journal:  World J Gastroenterol       Date:  2006-08-07       Impact factor: 5.742

5.  Dietary fatty acids regulate cholesterol induction of liver CYP7alpha1 expression and bile acid production.

Authors:  Yan Li; Meng Jun Hou; Jing Ma; Zhi Hong Tang; Hui Lian Zhu; Wen Hua Ling
Journal:  Lipids       Date:  2005-05       Impact factor: 1.880

Review 6.  Bile Acid Uptake Transporters as Targets for Therapy.

Authors:  Davor Slijepcevic; Stan F J van de Graaf
Journal:  Dig Dis       Date:  2017-03-01       Impact factor: 2.404

7.  Repression of hepatocyte nuclear factor 4 alpha by AP-1 underlies dyslipidemia associated with retinoic acid.

Authors:  Kyoung-Jae Won; Joo-Seop Park; Hyunyoung Jeong
Journal:  J Lipid Res       Date:  2019-02-01       Impact factor: 5.922

Review 8.  Mechanisms of disease: Inborn errors of bile acid synthesis.

Authors:  Shikha S Sundaram; Kevin E Bove; Mark A Lovell; Ronald J Sokol
Journal:  Nat Clin Pract Gastroenterol Hepatol       Date:  2008-06-24

9.  Potency of individual bile acids to regulate bile acid synthesis and transport genes in primary human hepatocyte cultures.

Authors:  Jie Liu; Hong Lu; Yuan-Fu Lu; Xiaohong Lei; Julia Yue Cui; Ewa Ellis; Stephen C Strom; Curtis D Klaassen
Journal:  Toxicol Sci       Date:  2014-07-23       Impact factor: 4.849

10.  Human cholesterol 7alpha-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype.

Authors:  Clive R Pullinger; Celeste Eng; Gerald Salen; Sarah Shefer; Ashok K Batta; Sandra K Erickson; Andrea Verhagen; Christopher R Rivera; Sean J Mulvihill; Mary J Malloy; John P Kane
Journal:  J Clin Invest       Date:  2002-07       Impact factor: 14.808
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.