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Literature DB >> 11559640

New horizons in the regulation of bile acid and lipid homeostasis: critical role of the nuclear receptor FXR as an intracellular bile acid sensor.

M Arrese¹, S J Karpen.

Abstract

Entities: Chemical Gene

Mesh：

Substances：

Year: 2001 PMID： 11559640 PMCID： PMC1728466 DOI： 10.1136/gut.49.4.465

Source DB: PubMed Journal: Gut ISSN： 0017-5749 Impact factor: 23.059

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14 in total

Review 1. "Don't know much bile-ology".

Authors: A Chawla; E Saez; R M Evans
Journal: Cell Date: 2000-09-29 Impact factor: 41.582

Review 2. The continuing importance of bile acids in liver and intestinal disease.

Authors: A F Hofmann
Journal: Arch Intern Med Date: 1999 Dec 13-27

3. The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp.

Authors: L A Denson; E Sturm; W Echevarria; T L Zimmerman; M Makishima; D J Mangelsdorf; S J Karpen
Journal: Gastroenterology Date: 2001-07 Impact factor: 22.682

4. An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.

Authors: W Xie; A Radominska-Pandya; Y Shi; C M Simon; M C Nelson; E S Ong; D J Waxman; R M Evans
Journal: Proc Natl Acad Sci U S A Date: 2001-03-13 Impact factor: 11.205

5. The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity.

Authors: J L Staudinger; B Goodwin; S A Jones; D Hawkins-Brown; K I MacKenzie; A LaTour; Y Liu; C D Klaassen; K K Brown; J Reinhard; T M Willson; B H Koller; S A Kliewer
Journal: Proc Natl Acad Sci U S A Date: 2001-03-13 Impact factor: 11.205

6. Bile salts mediate hepatocyte apoptosis by increasing cell surface trafficking of Fas.

Authors: T Sodeman; S F Bronk; P J Roberts; H Miyoshi; G J Gores
Journal: Am J Physiol Gastrointest Liver Physiol Date: 2000-06 Impact factor: 4.052

7. Bile acids: natural ligands for an orphan nuclear receptor.

Authors: D J Parks; S G Blanchard; R K Bledsoe; G Chandra; T G Consler; S A Kliewer; J B Stimmel; T M Willson; A M Zavacki; D D Moore; J M Lehmann
Journal: Science Date: 1999-05-21 Impact factor: 47.728

Review 8. Hepatic transport of bile salts.

Authors: G A Kullak-Ublick; B Stieger; B Hagenbuch; P J Meier
Journal: Semin Liver Dis Date: 2000 Impact factor: 6.115

New horizons in the regulation of bile acid and lipid homeostasis: critical role of the nuclear receptor FXR as an intracellular bile acid sensor.

Review 1. "Don't know much bile-ology".

Review 2. The continuing importance of bile acids in liver and intestinal disease.

3. The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp.

4. An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.

5. The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity.

6. Bile salts mediate hepatocyte apoptosis by increasing cell surface trafficking of Fas.

7. Bile acids: natural ligands for an orphan nuclear receptor.

Review 8. Hepatic transport of bile salts.

9. A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis.

10. Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors.

Review 1. The bile salt export pump: molecular properties, function and regulation.

2. Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis.

3. PPARα-UGT axis activation represses intestinal FXR-FGF15 feedback signalling and exacerbates experimental colitis.