OBJECTIVE: To study the seroprevalence of Kaposi's sarcoma-associated herpesvirus/human herpesvirus type 8 (KSHV/HHV-8) in 779 Italian blood donors. STUDY DESIGN/ METHODS: Sera were tested for antibodies to a latency-associated nuclear antigen (LANA) and a capsid related protein encoded by ORF65. RESULTS: Among all Italian donors, 17.7% and 18.7% had antibodies to LANA and ORF65 protein, respectively, and 24.1% had antibodies to at least one antigen. KSHV/HHV-8 seroprevalence was higher in the Po valley and in Sardinia than close to the sub-Alpine Veneto region, Tuscany, or Apulia. KSHV/HHV-8 seroprevalence was almost equally distributed between men and women but increased in the older age groups. CONCLUSIONS: The regional differences and age distribution in seroprevalence agree partially with the incidence of classic KS in Italy. The rarity of classic KS in KSHV/HHV-8-infected subjects and the equal gender distribution of seroprevalence suggest that other cofactors may contribute to KS development in human immunodeficiency virus type 1 (HIV-1)-uninfected individuals.
OBJECTIVE: To study the seroprevalence of Kaposi's sarcoma-associated herpesvirus/humanherpesvirus type 8 (KSHV/HHV-8) in 779 Italian blood donors. STUDY DESIGN/ METHODS: Sera were tested for antibodies to a latency-associated nuclear antigen (LANA) and a capsid related protein encoded by ORF65. RESULTS: Among all Italian donors, 17.7% and 18.7% had antibodies to LANA and ORF65 protein, respectively, and 24.1% had antibodies to at least one antigen. KSHV/HHV-8 seroprevalence was higher in the Po valley and in Sardinia than close to the sub-Alpine Veneto region, Tuscany, or Apulia. KSHV/HHV-8 seroprevalence was almost equally distributed between men and women but increased in the older age groups. CONCLUSIONS: The regional differences and age distribution in seroprevalence agree partially with the incidence of classic KS in Italy. The rarity of classic KS in KSHV/HHV-8-infected subjects and the equal gender distribution of seroprevalence suggest that other cofactors may contribute to KS development in humanimmunodeficiency virus type 1 (HIV-1)-uninfected individuals.
Authors: Andrea Lisco; Massimo Barbierato; Josè R Fiore; Paola Gasperini; Anna Favia; Anna Volpe; Maria Chironna; Giuseppe Pastore; Luigi Chieco-Bianchi; Maria Luisa Calabrò Journal: J Clin Microbiol Date: 2006-08-30 Impact factor: 5.948
Authors: C Cermelli; M Vinceti; F Beretti; V Pietrini; G Nacci; P Pietrosemoli; A Bartoletti; D Guidetti; P Sola; M Bergomi; G Vivoli; M Portolani Journal: Eur J Epidemiol Date: 2003 Impact factor: 8.082
Authors: Silvia Della Bella; Adriano Taddeo; Elena Colombo; Lucia Brambilla; Monica Bellinvia; Fabrizio Pregliasco; Monica Cappelletti; Maria Luisa Calabrò; Maria Luisa Villa Journal: PLoS One Date: 2010-11-29 Impact factor: 3.240
Authors: Michael Sand; Daniel Sand; Christina Thrandorf; Volker Paech; Peter Altmeyer; Falk G Bechara Journal: Head Face Med Date: 2010-06-04 Impact factor: 2.151