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Literature DB >> 12642004

Human Herpesvirus 8: Biology and Role in the Pathogenesis of Kaposi's Sarcoma and Other AIDS-related Malignancies.

Abel Viejo-Borbolla¹, Matthias Ottinger, Thomas F. Schulz.

Abstract

Human herpesvirus type 8, or Kaposi's sarcoma-associated herpesvirus (KSHV), is the only known human g(2) herpesvirus (rhadinovirus) and the most recently discovered tumor virus. KSHV is associated with Kaposi's sarcoma and two other lymphoproliferative disorders in the AIDS setting: primary effusion lymphoma and the plasma cell variant of multicentric Castleman's disease. This review offers an update on the epidemiology and the role of KSHV genes in the development of disease.

Entities: Disease Species

Year: 2003 PMID： 12642004 DOI： 10.1007/s11908-003-0054-2

Source DB: PubMed Journal: Curr Infect Dis Rep ISSN： 1523-3847 Impact factor: 3.725

55 in total

1. Downregulation of major histocompatibility complex class I molecules by Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins.

Authors: S Ishido; C Wang; B S Lee; G B Cohen; J U Jung
Journal: J Virol Date: 2000-06 Impact factor: 5.103

2. The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus supports latent DNA replication in dividing cells.

Authors: Jianhong Hu; Alexander C Garber; Rolf Renne
Journal: J Virol Date: 2002-11 Impact factor: 5.103

3. The lytic switch protein of KSHV activates gene expression via functional interaction with RBP-Jkappa (CSL), the target of the Notch signaling pathway.

Authors: Yuying Liang; Jean Chang; Stephen J Lynch; David M Lukac; Don Ganem
Journal: Genes Dev Date: 2002-08-01 Impact factor: 11.361

4. Identification of kaposin (open reading frame K12) as a human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus) transforming gene.

Authors: S Muralidhar; A M Pumfery; M Hassani; M R Sadaie; M Kishishita; J N Brady; J Doniger; P Medveczky; L J Rosenthal
Journal: J Virol Date: 1998-06 Impact factor: 5.103

5. Kaposi's sarcoma-associated herpesvirus K3 utilizes the ubiquitin-proteasome system in routing class major histocompatibility complexes to late endocytic compartments.

Authors: Mayra E Lorenzo; Jae U Jung; Hidde L Ploegh
Journal: J Virol Date: 2002-06 Impact factor: 5.103

6. Human herpesvirus 8 LANA interacts with proteins of the mSin3 corepressor complex and negatively regulates Epstein-Barr virus gene expression in dually infected PEL cells.

Authors: A Krithivas; D B Young; G Liao; D Greene; S D Hayward
Journal: J Virol Date: 2000-10 Impact factor: 5.103

7. Bone marrow failure associated with human herpesvirus 8 infection after transplantation.

Authors: M Luppi; P Barozzi; T F Schulz; G Setti; K Staskus; R Trovato; F Narni; A Donelli; A Maiorana; R Marasca; S Sandrini; G Torelli
Journal: N Engl J Med Date: 2000-11-09 Impact factor: 91.245

8. The human herpes virus 8-encoded viral FLICE inhibitory protein physically associates with and persistently activates the Ikappa B kinase complex.

Authors: Li Liu; Michael T Eby; Nisha Rathore; Suwan K Sinha; Arvind Kumar; Preet M Chaudhary
Journal: J Biol Chem Date: 2002-02-05 Impact factor: 5.157

9. The immunogenic glycoprotein gp35-37 of human herpesvirus 8 is encoded by open reading frame K8.1.

Authors: M S Raab; J C Albrecht; A Birkmann; S Yağuboğlu; D Lang; B Fleckenstein; F Neipel
Journal: J Virol Date: 1998-08 Impact factor: 5.103

10. Prevalence and determinants of anti-lytic and anti-latent antibodies to human herpesvirus-8 among Italian individuals at risk of sexually and parenterally transmitted infections.

Authors: G Rezza; E T Lennette; M Giuliani; P Pezzotti; F Caprilli; P Monini; S Buttò; G Lodi; A Di Carlo; J A Levy; B Ensoli
Journal: Int J Cancer Date: 1998-07-29 Impact factor: 7.396

8 in total

1. Kaposi's sarcoma-associated herpesvirus K8beta is derived from a spliced intermediate of K8 pre-mRNA and antagonizes K8alpha (K-bZIP) to induce p21 and p53 and blocks K8alpha-CDK2 interaction.

Authors: Koji Yamanegi; Shuang Tang; Zhi-Ming Zheng
Journal: J Virol Date: 2005-11 Impact factor: 5.103

2. The targeting of primary effusion lymphoma cells for apoptosis by inducing lytic replication of human herpesvirus 8 while blocking virus production.

Authors: Carmen M Klass; Laurie T Krug; Veronika P Pozharskaya; Margaret K Offermann
Journal: Blood Date: 2005-02-01 Impact factor: 22.113

3. Establishment of an ELISA to detect Kaposi's sarcoma-associated herpesvirus using recombinant ORF73.

Authors: Xin-xing Ouyang; Bi-shi Fu; Bao-lin Li; Yan Zeng; Fan-hong Xu; Lin-ding Wang
Journal: Virol Sin Date: 2010-06-06 Impact factor: 4.327

4. Kaposi's sarcoma-associated herpesvirus ORF57 functions as a viral splicing factor and promotes expression of intron-containing viral lytic genes in spliceosome-mediated RNA splicing.

Authors: Vladimir Majerciak; Koji Yamanegi; Eric Allemand; Michael Kruhlak; Adrian R Krainer; Zhi-Ming Zheng
Journal: J Virol Date: 2008-01-09 Impact factor: 5.103

5. KSHV reactivation from latency requires Pim-1 and Pim-3 kinases to inactivate the latency-associated nuclear antigen LANA.

Authors: Fang Cheng; Magdalena Weidner-Glunde; Markku Varjosalo; Eeva-Marja Rainio; Anne Lehtonen; Thomas F Schulz; Päivi J Koskinen; Jussi Taipale; Päivi M Ojala
Journal: PLoS Pathog Date: 2009-03-06 Impact factor: 6.823