B J Stenson1, L Middlemist, A J Lyon. 1. Neonatal Unit, Simpson Memorial Maternity Pavilion, Edinburgh. Stensonb@telemedicine.clh.ed.ac.uk
Abstract
AIM: To determine the effect of erythromycin on the establishment of enteral feeding in ventilated infants < 31 weeks gestation. METHODS:Erythromycin was randomly allocated as an antimicrobial treatment for the first 7 days of life in 76 infants: 35 received erythromycin and 41 acted as controls. Feed toleration, time taken to establish full enteral feeding, vomiting, prescription of glycerine suppositories and occurrence of necrotising enterocolitis were recorded. RESULTS: There were no significant differences between the groups for any of the outcomes. The infants treated with erythromycin reached full feeding at a median (quartile) age of 8 (5-12) days compared with 9 (6-14) days for controls. CONCLUSIONS:Intravenous erythromycin in antimicrobial doses is unlikely to benefit the introduction of feeding in preterm infants.
RCT Entities:
AIM: To determine the effect of erythromycin on the establishment of enteral feeding in ventilated infants < 31 weeks gestation. METHODS:Erythromycin was randomly allocated as an antimicrobial treatment for the first 7 days of life in 76 infants: 35 received erythromycin and 41 acted as controls. Feed toleration, time taken to establish full enteral feeding, vomiting, prescription of glycerine suppositories and occurrence of necrotising enterocolitis were recorded. RESULTS: There were no significant differences between the groups for any of the outcomes. The infants treated with erythromycin reached full feeding at a median (quartile) age of 8 (5-12) days compared with 9 (6-14) days for controls. CONCLUSIONS: Intravenous erythromycin in antimicrobial doses is unlikely to benefit the introduction of feeding in preterm infants.
Authors: P C Ng; K W So; K S Fung; C H Lee; T F Fok; E Wong; W Wong; K L Cheung; A F Cheng Journal: Arch Dis Child Fetal Neonatal Ed Date: 2001-05 Impact factor: 5.747
Authors: Pak C Ng; Cheuk H Lee; Samuel P S Wong; Hugh S Lam; Flora Y B Liu; King W So; Cheuk Y Lee; Tai F Fok Journal: Gastroenterology Date: 2007-03-24 Impact factor: 22.682