BACKGROUND/AIMS: Gastrin is a trophic factor within the normal gastrointestinal tract and is also a mitogen for a number of gastrointestinal and non-gastrointestinal tumours. Precursor forms of gastrin including progastrin (proG) and glycine-extended gastrin (G-gly) as well as the fully processed amidated gastrin (G-NH2) are expressed by tumours. There has been little study of the role of gastrin in either normal liver or liver tumours. The aim of this study was to identify the expression of CCK-B/gastrin receptor (CCK-BR), proG, G-gly and G-NH2 in normal liver and liver tumours. METHODS: Tissue sections from patients with hepatocellular carcinoma, fibrolamellar carcinoma, cholangiocarcinoma as well as normal liver biopsies were assessed for expression of CCK-BR and gastrin isoforms. RESULTS: Most liver tumours express CCK-BR and are able to process gastrin as far as proG and G-gly, although not as far as the amidated form. There appears to be little expression of the receptor and no expression of precursor forms of gastrin in normal liver. CONCLUSIONS: Liver tumours express the CCK-BR and precursor forms of gastrin. This expression may be associated with tumour proliferation.
BACKGROUND/AIMS: Gastrin is a trophic factor within the normal gastrointestinal tract and is also a mitogen for a number of gastrointestinal and non-gastrointestinal tumours. Precursor forms of gastrin including progastrin (proG) and glycine-extended gastrin (G-gly) as well as the fully processed amidated gastrin (G-NH2) are expressed by tumours. There has been little study of the role of gastrin in either normal liver or liver tumours. The aim of this study was to identify the expression of CCK-B/gastrin receptor (CCK-BR), proG, G-gly and G-NH2 in normal liver and liver tumours. METHODS: Tissue sections from patients with hepatocellular carcinoma, fibrolamellar carcinoma, cholangiocarcinoma as well as normal liver biopsies were assessed for expression of CCK-BR and gastrin isoforms. RESULTS: Most liver tumours express CCK-BR and are able to process gastrin as far as proG and G-gly, although not as far as the amidated form. There appears to be little expression of the receptor and no expression of precursor forms of gastrin in normal liver. CONCLUSIONS:Liver tumours express the CCK-BR and precursor forms of gastrin. This expression may be associated with tumour proliferation.
Authors: Shigeo Takaishi; Wataru Shibata; Hiroyuki Tomita; Guangchun Jin; Xiangdong Yang; Russell Ericksen; Zinaida Dubeykovskaya; Samuel Asfaha; Michael Quante; Kelly S Betz; Arthur Shulkes; Timothy C Wang Journal: Am J Physiol Gastrointest Liver Physiol Date: 2010-11-04 Impact factor: 4.052
Authors: Peter C Konturek; Kazimierz Rembiasz; Grzegorz Burnat; Stanisław J Konturek; Marcin Tusinela; Władysław Bielanski; Jens Rehfeld; Danuta Karcz; Eckhart Hahn Journal: Dig Dis Sci Date: 2006-04 Impact factor: 3.199
Authors: Carlo Fabbri; M Francesca Jaboli; Silvia Giovanelli; Francesco Azzaroli; Alessandro Pezzoli; Esterita Accogli; Stefania Liva; Giovanni Nigro; Anna Miracolo; Davide Festi; Antonio Colecchia; Marco Montagnani; Enrico Roda; Giuseppe Mazzella Journal: World J Gastroenterol Date: 2003-07 Impact factor: 5.742
Authors: Peter C Konturek; Władysław Bielanski; Stanislaw J Konturek; Artur Hartwich; Piotr Pierzchalski; Macien Gonciarz; Krzysztof Marlicz; Teresa Starzynska; Monika Zuchowicz; Zbigniew Darasz; Jens P Götze; Jens F Rehfeld; Eckhart G Hahn Journal: Dig Dis Sci Date: 2002-09 Impact factor: 3.199
Authors: Michael R Paillasse; Philippe de Medina; Guillaume Amouroux; Loubna Mhamdi; Marc Poirot; Sandrine Silvente-Poirot Journal: J Lipid Res Date: 2009-06-05 Impact factor: 5.922