Literature DB >> 10189230

Thio sugars: biological relevance as potential new therapeutics.

Z J Witczak1.   

Abstract

The biological relevance of sulfur containing carbohydrates is gaining substantial attention. Thus the new developments, especially in the synthetic and medicinal chemistry of thio-sugars are critically important for carbohydrate drug design. New studies of biological processes including biosynthetic reactions and enzyme control mechanisms, discovered during the last few years clearly contributed to an understanding of their biological roles. These roles of carbohydrates and thio-sugars in particular through biological processes and diseases are becoming better understood now. These new trends will provide tremendous opportunities for the development of carbohydrates as new potential drugs. The main objective of this article is to address these new promising advances

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Year:  1999        PMID: 10189230

Source DB:  PubMed          Journal:  Curr Med Chem        ISSN: 0929-8673            Impact factor:   4.530


  12 in total

1.  Synthesis and Evaluation of Oligomeric Thioether-Linked Carbacyclic β-(1→3)-Glucan Mimetics.

Authors:  Peng Wen; Václav Větvička; David Crich
Journal:  J Org Chem       Date:  2019-04-15       Impact factor: 4.354

Review 2.  Expanding the enzyme universe: accessing non-natural reactions by mechanism-guided directed evolution.

Authors:  Hans Renata; Z Jane Wang; Frances H Arnold
Journal:  Angew Chem Int Ed Engl       Date:  2015-02-03       Impact factor: 15.336

3.  Synthesis and Evaluation of 1,5-Dithia-d-laminaribiose, Triose, and Tetraose as Truncated β-(1→3)-Glucan Mimetics.

Authors:  Xiaoxiao Liao; Václav Větvička; David Crich
Journal:  J Org Chem       Date:  2018-12-04       Impact factor: 4.354

4.  An armed-disarmed approach for blocking aglycon transfer of thioglycosides.

Authors:  Zhitao Li; Jeffrey C Gildersleeve
Journal:  Tetrahedron Lett       Date:  2007-01-22       Impact factor: 2.415

5.  Conformational analysis of thioglycoside derivatives of histo-blood group ABH antigens using an ab initio-derived reparameterization of MM4: implications for design of non-hydrolysable mimetics.

Authors:  Francesco Strino; Jenn-Huei Lii; Hans-Joachim Gabius; Per-Georg Nyholm
Journal:  J Comput Aided Mol Des       Date:  2009-09-15       Impact factor: 3.686

6.  Probing the substrate specificity of Golgi alpha-mannosidase II by use of synthetic oligosaccharides and a catalytic nucleophile mutant.

Authors:  Wei Zhong; Douglas A Kuntz; Brian Ember; Harminder Singh; Kelley W Moremen; David R Rose; Geert-Jan Boons
Journal:  J Am Chem Soc       Date:  2008-06-18       Impact factor: 15.419

7.  Efficient synthesis of 4-sulfanylcoumarins from 3-bromo-coumarins via a highly selective DABCO-mediated one-pot thia-Michael addition/elimination process.

Authors:  Vitor B Mostardeiro; Marina C Dilelio; Teodoro S Kaufman; Claudio C Silveira
Journal:  RSC Adv       Date:  2020-01-02       Impact factor: 4.036

8.  Photoinitiated Thiol-ene Reactions of Enoses: A Powerful Tool for Stereoselective Synthesis of Glycomimetics with Challenging Glycosidic Linkages.

Authors:  Anikó Borbás
Journal:  Chemistry       Date:  2020-03-19       Impact factor: 5.236

9.  Evaluation of the Mycobactericidal Effect of Thio-functionalized Carbohydrate Derivatives.

Authors:  Małgorzata Korycka-Machała; Anna Brzostek; Bożena Dziadek; Malwina Kawka; Tomasz Popławski; Zbigniew J Witczak; Jarosław Dziadek
Journal:  Molecules       Date:  2017-05-16       Impact factor: 4.411

10.  Direct, stereoselective thioglycosylation enabled by an organophotoredox radical strategy.

Authors:  Peng Ji; Yueteng Zhang; Feng Gao; Fangchao Bi; Wei Wang
Journal:  Chem Sci       Date:  2020-10-19       Impact factor: 9.825

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