Literature DB >> 10102440

Neurofilament protein levels in CSF are increased in dementia.

L E Rosengren1, J E Karlsson, M Sjögren, K Blennow, A Wallin.   

Abstract

The neurofilament is the major cytoskeletal structure of myelinated axons. In this study, CSF levels of the light subunit of the neurofilament protein (NFL) were increased in patients with vascular dementia (VAD), AD, and frontotemporal dementia (FTD) compared with neurologically healthy individuals. Because NFL is localized mainly in myelinated axons, these results suggest that the degeneration of white matter in these disorders causes the increased CSF NFL levels.

Entities:  

Mesh：

Substances：

Year:  1999        PMID： 10102440     DOI： 10.1212/wnl.52.5.1090

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  44 in total

Review 1.  Frontotemporal dementia and tauopathy.

Authors:  Y Yoshiyama; V M Lee; J Q Trojanowski
Journal:  Curr Neurol Neurosci Rep       Date:  2001-09       Impact factor: 5.081

2.  Association of Cerebrospinal Fluid Neurofilament Light Protein Levels With Cognition in Patients With Dementia, Motor Neuron Disease, and Movement Disorders.

Authors:  Bob Olsson; Erik Portelius; Nicholas C Cullen; Åsa Sandelius; Henrik Zetterberg; Ulf Andreasson; Kina Höglund; David J Irwin; Murray Grossman; Daniel Weintraub; Alice Chen-Plotkin; David Wolk; Leo McCluskey; Lauren Elman; Leslie M Shaw; Jon B Toledo; Jennifer McBride; Pilar Hernandez-Con; Virginia M-Y Lee; John Q Trojanowski; Kaj Blennow
Journal:  JAMA Neurol       Date:  2019-03-01       Impact factor: 18.302

3.  Inhibition of melatonin biosynthesis induces neurofilament hyperphosphorylation with activation of cyclin-dependent kinase 5.

Authors:  Shaohui Wang; Lingqiang Zhu; Hairong Shi; Hongyun Zheng; Qing Tian; Qun Wang; Rong Liu; Jian-Zhi Wang
Journal:  Neurochem Res       Date:  2007-03-31       Impact factor: 3.996

Review 4.  SILK studies - capturing the turnover of proteins linked to neurodegenerative diseases.

Authors:  Ross W Paterson; Audrey Gabelle; Brendan P Lucey; Nicolas R Barthélemy; Claire A Leckey; Christophe Hirtz; Sylvain Lehmann; Chihiro Sato; Bruce W Patterson; Tim West; Kevin Yarasheski; Jonathan D Rohrer; Norelle C Wildburger; Jonathan M Schott; Celeste M Karch; Selina Wray; Timothy M Miller; Donald L Elbert; Henrik Zetterberg; Nick C Fox; Randall J Bateman
Journal:  Nat Rev Neurol       Date:  2019-06-20       Impact factor: 42.937

Review 5.  Cerebrospinal fluid protein biomarkers for Alzheimer's disease.

Authors:  Kaj Blennow
Journal:  NeuroRx       Date:  2004-04

6.  Levels of cerebrospinal fluid neurofilament light protein in healthy elderly vary as a function of TOMM40 variants.

Authors:  Davide Bruno; Nunzio Pomara; Jay Nierenberg; James C Ritchie; Michael W Lutz; Henrik Zetterberg; Kaj Blennow
Journal:  Exp Gerontol       Date:  2011-10-01       Impact factor: 4.032

7.  Cerebrospinal fluid analysis should be considered in patients with cognitive problems.

Authors:  Henrik Zetterberg; Niklas Mattsson; Kaj Blennow
Journal:  Int J Alzheimers Dis       Date:  2010-07-14

8.  CSF Biomarkers for Alzheimer's Disease Diagnosis.

Authors:  A Anoop; Pradeep K Singh; Reeba S Jacob; Samir K Maji
Journal:  Int J Alzheimers Dis       Date:  2010-06-23

Review 9.  Peptides and proteins in plasma and cerebrospinal fluid as biomarkers for the prediction, diagnosis, and monitoring of therapeutic efficacy of Alzheimer's disease.

Authors:  Christopher D Aluise; Renã A Sowell; D Allan Butterfield
Journal:  Biochim Biophys Acta       Date:  2008-08-07

10.  Detection of glial fibrillary acidic protein and neurofilaments in the cerebrospinal fluid of patients with neurocysticercosis.

Authors:  J Luis Quintanar; Luis Manuel Franco; Eva Salinas
Journal:  Parasitol Res       Date:  2003-03-12       Impact factor: 2.289
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.