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Literature DB >> 10101801

p53 and apoptosis.

Abstract

One of the several biological functions attributed to p53 is the ability to induce apoptotic cell suicide. It has become clear that this apoptotic activity of p53 is central to its role as a tumor suppressor. A summary of current knowledge concerning the mechanisms of p53-mediated apoptosis is presented. The pivotal 'choice' between p53-induced viable growth arrest and apoptosis is discussed.

Entities: Disease Gene

Mesh：

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Year: 1998 PMID： 10101801 DOI： 10.1006/scbi.1998.0098

Source DB: PubMed Journal: Semin Cancer Biol ISSN： 1044-579X Impact factor: 15.707

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Cited

39 in total

1. Identification and classification of p53-regulated genes.

Authors: J Yu; L Zhang; P M Hwang; C Rago; K W Kinzler; B Vogelstein
Journal: Proc Natl Acad Sci U S A Date: 1999-12-07 Impact factor: 11.205

2. The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription.

Authors: J S Steffan; A Kazantsev; O Spasic-Boskovic; M Greenwald; Y Z Zhu; H Gohler; E E Wanker; G P Bates; D E Housman; L M Thompson
Journal: Proc Natl Acad Sci U S A Date: 2000-06-06 Impact factor: 11.205

3. WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase.

Authors: Fei Su; Michael Overholtzer; Daniel Besser; Arnold J Levine
Journal: Genes Dev Date: 2002-01-01 Impact factor: 11.361

4. Integrity of the N-terminal transcription domain of p53 is required for mutant p53 interference with drug-induced apoptosis.

Authors: D Matas; A Sigal; P Stambolsky; M Milyavsky; L Weisz; D Schwartz; N Goldfinger; V Rotter
Journal: EMBO J Date: 2001-08-01 Impact factor: 11.598

5. Carboxy terminus of human herpesvirus 8 latency-associated nuclear antigen mediates dimerization, transcriptional repression, and targeting to nuclear bodies.

Authors: D R Schwam; R L Luciano; S S Mahajan; L Wong; A C Wilson
Journal: J Virol Date: 2000-09 Impact factor: 5.103

p53 and apoptosis.

1. Identification and classification of p53-regulated genes.

2. The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription.

3. WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase.

4. Integrity of the N-terminal transcription domain of p53 is required for mutant p53 interference with drug-induced apoptosis.

5. Carboxy terminus of human herpesvirus 8 latency-associated nuclear antigen mediates dimerization, transcriptional repression, and targeting to nuclear bodies.

Review 6. p53's believe it or not: lessons on transcription-independent death.

7. PUMA mediates the apoptotic response to p53 in colorectal cancer cells.

Review 8. The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer.

Review 9. The cell cycle: a critical therapeutic target to prevent vascular proliferative disease.

10. Bidentate ligands on osmium(VI) nitrido complexes control intracellular targeting and cell death pathways.