BACKGROUND: Resection of pulmonary or hepatic colorectal metastases is associated with a 5-year survival rate of 25-40 per cent. This report analyses outcome following sequential resection of colorectal metastases to both organs. METHODS: Seventeen patients with histologically confirmed colorectal adenocarcinoma and resection of liver and lung metastases were identified from a prospective database. RESULTS: The median interval between resection of the primary tumour and first metastasis was 21 (range 0-64) months. The interval between resection of the first and subsequent metastases was 18 (range 1-74) months. No patient died in the postoperative period and there were two perioperative complications. The overall survival rate in 17 patients was 70 per cent at 2 years from resection of metastasis to the second organ, but the disease-free survival rate at 2 years was only 24 per cent. CONCLUSION: Although few long-term survivors were observed in this small series, sequential resection of hepatic and pulmonary metastases is warranted in a highly selected group of patients.
BACKGROUND: Resection of pulmonary or hepatic colorectal metastases is associated with a 5-year survival rate of 25-40 per cent. This report analyses outcome following sequential resection of colorectal metastases to both organs. METHODS: Seventeen patients with histologically confirmed colorectal adenocarcinoma and resection of liver and lung metastases were identified from a prospective database. RESULTS: The median interval between resection of the primary tumour and first metastasis was 21 (range 0-64) months. The interval between resection of the first and subsequent metastases was 18 (range 1-74) months. No patient died in the postoperative period and there were two perioperative complications. The overall survival rate in 17 patients was 70 per cent at 2 years from resection of metastasis to the second organ, but the disease-free survival rate at 2 years was only 24 per cent. CONCLUSION: Although few long-term survivors were observed in this small series, sequential resection of hepatic and pulmonary metastases is warranted in a highly selected group of patients.
Authors: Benny Johnson; Zhaohui Jin; Michael G Haddock; Christopher L Hallemeier; James A Martenson; Rory L Smoot; David W Larson; Eric J Dozois; David M Nagorney; Axel Grothey Journal: Oncologist Date: 2018-02-14
Authors: Georgios Meimarakis; Martin Angele; Claudius Conrad; Rolf Schauer; Rolf Weidenhagen; Alexander Crispin; Clemens Giessen; Gerhard Preissler; Max Wiedemann; Karl-Walter Jauch; Volker Heinemann; Sebastian Stintzing; Rudolf A Hatz; Hauke Winter Journal: Langenbecks Arch Surg Date: 2013-01-13 Impact factor: 3.445
Authors: Albert Dirisamer; Benjamin S Halpern; Wolfgang Schima; Martin Heinisch; Florian Wolf; Mohsen Beheshti; Franz Dirisamer; Michael Weber; Werner Langsteger Journal: Mol Imaging Biol Date: 2008-08-16 Impact factor: 3.488