Literature DB >> 10098672

Sialidase inhibitors related to zanamivir: synthesis and biological evaluation of 4H-pyran 6-ether and ketone.

P W Smith1, J E Robinson, D N Evans, S L Sollis, P D Howes, N Trivedi, R C Bethell.   

Abstract

Synthesis of 5R-Acetamido-4S-amino-4H-pyran-6R-O-( -ethyl)propyl and 6R-(1-oxo-2-ethyl)butyl 2-carboxylic acids (4 and 5) and their evaluation as inhibitors of influenza virus sialidase is described. Both compounds showed good inhibitory activity with marked selectivity for influenza A sialidase.

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Year:  1999        PMID： 10098672     DOI： 10.1016/s0960-894x(99)00031-1

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Unsaturated N-acetyl- D-glucosaminuronic acid glycosides as inhibitors of influenza virus sialidase.

Authors:  Maretta C Mann; Tasneem Islam; Jeffrey C Dyason; Pas Florio; Carolyn J Trower; Robin J Thomson; Mark von Itzstein
Journal:  Glycoconj J       Date:  2006-02       Impact factor: 2.916

2.  Scoring ensembles of docked protein:ligand interactions for virtual lead optimization.

Authors:  Janet L Paulsen; Amy C Anderson
Journal:  J Chem Inf Model       Date:  2009-12       Impact factor: 4.956

3.  Crystal structure of a new benzoic acid inhibitor of influenza neuraminidase bound with a new tilt induced by overpacking subsite C6.

Authors:  Lalitha Venkatramani; Eric S Johnson; Gundurao Kolavi; Gillian M Air; Wayne J Brouillette; Blaine H M Mooers
Journal:  BMC Struct Biol       Date:  2012-05-06

Review 4.  Anti-influenza virus agents: synthesis and mode of action.

Authors:  Irene M Lagoja; Erik De Clercq
Journal:  Med Res Rev       Date:  2008-01       Impact factor: 12.944
  4 in total

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