Literature DB >> 10098409

It's a noisy business! Genetic regulation at the nanomolar scale.

H H McAdams1, A Arkin.   

Abstract

Many molecules that control genetic regulatory circuits act at extremely low intracellular concentrations. Resultant fluctuations (noise) in reaction rates cause large random variation in rates of development, morphology and the instantaneous concentration of each molecular species in each cell. To achieve regulatory reliability in spite of this noise, cells use redundancy in genes as well as redundancy and extensive feedback in regulatory pathways. However, some regulatory mechanisms exploit this noise to randomize outcomes where variability is advantageous.

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Year:  1999        PMID: 10098409     DOI: 10.1016/s0168-9525(98)01659-x

Source DB:  PubMed          Journal:  Trends Genet        ISSN: 0168-9525            Impact factor:   11.639


  192 in total

1.  Stochastic focusing: fluctuation-enhanced sensitivity of intracellular regulation.

Authors:  J Paulsson; O G Berg; M Ehrenberg
Journal:  Proc Natl Acad Sci U S A       Date:  2000-06-20       Impact factor: 11.205

2.  Dynamic modeling of gene expression data.

Authors:  N S Holter; A Maritan; M Cieplak; N V Fedoroff; J R Banavar
Journal:  Proc Natl Acad Sci U S A       Date:  2001-02-13       Impact factor: 11.205

3.  Fluctuations in repressor control: thermodynamic constraints on stochastic focusing.

Authors:  O G Berg; J Paulsson; M Ehrenberg
Journal:  Biophys J       Date:  2000-12       Impact factor: 4.033

4.  Intrinsic noise in gene regulatory networks.

Authors:  M Thattai; A van Oudenaarden
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-03       Impact factor: 11.205

5.  Mechanisms of noise-resistance in genetic oscillators.

Authors:  José M G Vilar; Hao Yuan Kueh; Naama Barkai; Stanislas Leibler
Journal:  Proc Natl Acad Sci U S A       Date:  2002-04-23       Impact factor: 11.205

Review 6.  Through a genome, darkly: comparative analysis of plant chromosomal DNA.

Authors:  Graham J King
Journal:  Plant Mol Biol       Date:  2002-01       Impact factor: 4.076

7.  A power law for cells.

Authors:  R B Azevedo; A M Leroi
Journal:  Proc Natl Acad Sci U S A       Date:  2001-05-01       Impact factor: 11.205

8.  Attenuation of noise in ultrasensitive signaling cascades.

Authors:  Mukund Thattai; Alexander van Oudenaarden
Journal:  Biophys J       Date:  2002-06       Impact factor: 4.033

9.  Fluctuations and quality of control in biological cells: zero-order ultrasensitivity reinvestigated.

Authors:  O G Berg; J Paulsson; M Ehrenberg
Journal:  Biophys J       Date:  2000-09       Impact factor: 4.033

10.  Fluctuations and slow variables in genetic networks.

Authors:  R Bundschuh; F Hayot; C Jayaprakash
Journal:  Biophys J       Date:  2003-03       Impact factor: 4.033

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