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Literature DB >> 1009684

Binding of phytohaemagglutinin to serum substances and inhibition of lymphocyte transformation in Hodgkin's disease.

Abstract

Serum from eleven of fifty-four patients with Hodgkin's disease inhibited phytohaemagglutinin (PHA) stimulation of both autologous and homologous lymphocytes. The inhibitory effect resided in the macromolecular fraction of these sera. PHA was shown to bind to serum substances in inhibitory sera and the degree of PHA binding in the macromolecular fraction correlated directly with the extent of inhibition.

Entities: Disease Species

Mesh：

Substances：
Lectins

Year: 1976 PMID： 1009684 PMCID： PMC1540991

Source DB: PubMed Journal: Clin Exp Immunol ISSN： 0009-9104 Impact factor: 4.330

16 in total

1. THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY.

Authors: F C GREENWOOD; W M HUNTER; J S GLOVER
Journal: Biochem J Date: 1963-10 Impact factor: 3.857

2. Effect of phytohaemagglutinin on human serum and cell proteins.

Authors: L BECKMAN
Journal: Nature Date: 1962-08-11 Impact factor: 49.962

3. Studies on pregnancy-associated globulin.

Authors: C H Horne; A L McLay; H B Tavadia; I Carmichael; A C Mallinson; A A Laiwah; M A Thomas; R N MacSween
Journal: Clin Exp Immunol Date: 1973-04 Impact factor: 4.330

4. The effects of human serum fractions on phytohemagglutinin- and concanavalin A-stimulated human lymphocyte cultures.

Authors: P S Chase
Journal: Cell Immunol Date: 1972-12 Impact factor: 4.868

5. Reduced lymphocyte transformation in breast cancer.

Authors: M G Whittaker; K Rees; C G Clark
Journal: Lancet Date: 1971-05-01 Impact factor: 79.321

6. Lymphocyte response to P.H.A. in patients with non-lymphoid tumours.

Authors: D B Garrioch; R A Good; R A Gatti
Journal: Lancet Date: 1970-03-21 Impact factor: 79.321

7. Reduced lymphocyte transformation due to a plasma factor in patients with active syphilis.

Authors: G M Levene; J L Turk; D J Wright; A G Grimble
Journal: Lancet Date: 1969-08-02 Impact factor: 79.321

8. Impaired in vitro lymphocyte transformation in Hodgkin's disease.

Authors: E M Hersh; J J Oppenheim
Journal: N Engl J Med Date: 1965-11-04 Impact factor: 91.245

9. Lymphocyte response to phytohemagglutinin in Hodgkin's disease, lymphatic leukemia and lymphosarcoma.

Authors: S Trubowitz; B Masek; A Del Rosario
Journal: Cancer Date: 1966-12 Impact factor: 6.860

10. Recent immunological findins in Hodgkin's disease.

Authors: V Grifoni
Journal: Tumori Date: 1973 Sep-Oct

7 in total

1. Circulating immune complexes after repeated halothane anaesthesia.

Authors: B D Williams; N White; P L Amlot; J Slaney; P A Toseland
Journal: Br Med J Date: 1977-07-16

2. In vitro modulation of lymphocyte responses to phytohaemagglutinin by plasma in mother and baby at the time of birth. Increased lymphocyte responses in babies of mothers with lepromatous leprosy.

Authors: G Bjune; E Duncan; R S Barnetson; R Melsom
Journal: Clin Exp Immunol Date: 1978-06 Impact factor: 4.330