Literature DB >> 10092191

Brasilicardin A, a new terpenoid antibiotic from pathogenic Nocardia brasiliensis: fermentation, isolation and biological activity.

H Komaki1, A Nemoto, Y Tanaka, H Takagi, K Yazawa, Y Mikami, H Shigemori, J Kobayashi, A Ando, Y Nagata.   

Abstract

A novel tricyclic diterpenoid antibiotic, brasilicardin A, was isolated from the culture broth of Nocardia brasiliensis IFM 0406. The antibiotic exhibited immunosuppressive activity in a mouse mixed lymphocyte reaction (MLR) assay system and its IC50 value was 0.057 microg/ml. Although the inhibitory activity of cyclosporin A (CyA) against IL-2 production was confirmed in the MLR assay system, brasilicardin A did not have the activity. The results of in vitro toxicity testing of brasilicardin A against various human cell lines were compared with those of CyA.

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Year:  1999        PMID： 10092191     DOI： 10.7164/antibiotics.52.13

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  11 in total

Review 1.  Taxonomy, Physiology, and Natural Products of Actinobacteria.

Authors:  Essaid Ait Barka; Parul Vatsa; Lisa Sanchez; Nathalie Gaveau-Vaillant; Cedric Jacquard; Jan P Meier-Kolthoff; Hans-Peter Klenk; Christophe Clément; Yder Ouhdouch; Gilles P van Wezel
Journal:  Microbiol Mol Biol Rev       Date:  2015-11-25       Impact factor: 11.056

2.  Atolypenes, Tricyclic Bacterial Sesterterpenes Discovered Using a Multiplexed In Vitro Cas9-TAR Gene Cluster Refactoring Approach.

Authors:  Seong-Hwan Kim; Wanli Lu; Mahmoud Kamal Ahmadi; Daniel Montiel; Melinda A Ternei; Sean F Brady
Journal:  ACS Synth Biol       Date:  2018-12-21       Impact factor: 5.110

3.  Discovery of the Tiancilactone Antibiotics by Genome Mining of Atypical Bacterial Type II Diterpene Synthases.

Authors:  Liao-Bin Dong; Jeffrey D Rudolf; Ming-Rong Deng; Xiaohui Yan; Ben Shen
Journal:  Chembiochem       Date:  2018-05-27       Impact factor: 3.164

4.  Biosynthesis of a natural polyketide-isoprenoid hybrid compound, furaquinocin A: identification and heterologous expression of the gene cluster.

Authors:  Takashi Kawasaki; Yutaka Hayashi; Tomohisa Kuzuyama; Kazuo Furihata; Nobuya Itoh; Haruo Seto; Tohru Dairi
Journal:  J Bacteriol       Date:  2006-02       Impact factor: 3.490

Review 5.  Bacterial terpenome.

Authors:  Jeffrey D Rudolf; Tyler A Alsup; Baofu Xu; Zining Li
Journal:  Nat Prod Rep       Date:  2021-05-26       Impact factor: 15.111

6.  Structure, function and inhibition of ent-kaurene synthase from Bradyrhizobium japonicum.

Authors:  Wenting Liu; Xinxin Feng; Yingying Zheng; Chun-Hsiang Huang; Chiaki Nakano; Tsutomu Hoshino; Shannon Bogue; Tzu-Ping Ko; Chun-Chi Chen; Yunfeng Cui; Jian Li; Iren Wang; Shang-Te Danny Hsu; Eric Oldfield; Rey-Ting Guo
Journal:  Sci Rep       Date:  2014-10-01       Impact factor: 4.379

7.  Elucidation of the glycosylation steps during biosynthesis of antitumor macrolides PM100117 and PM100118 and engineering for novel derivatives.

Authors:  Raúl García Salcedo; Carlos Olano; Rogelio Fernández; Alfredo F Braña; Carmen Méndez; Fernando de la Calle; José A Salas
Journal:  Microb Cell Fact       Date:  2016-11-09       Impact factor: 5.328

8.  High-Quality Draft Genome Sequence of the Actinobacterium Nocardia terpenica IFM 0406, Producer of the Immunosuppressant Brasilicardins, Using Illumina and PacBio Technologies.

Authors:  Anina Buchmann; Michael Eitel; Pierre Koch; Paul N Schwarz; Evi Stegmann; Wolfgang Wohlleben; Marcin Wolański; Michał Krawiec; Jolanta Zakrzewska-Czerwińska; Carmen Méndez; Alma Botas; Luz Elena Núñez; Francisco Morís; Jesus Cortés; Harald Gross
Journal:  Genome Announc       Date:  2016-12-15

9.  Engineering metabolic pathways in Amycolatopsis japonicum for the optimization of the precursor supply for heterologous brasilicardin congeners production.

Authors:  Paul N Schwarz; Luisa Roller; Andreas Kulik; Wolfgang Wohlleben; Evi Stegmann
Journal:  Synth Syst Biotechnol       Date:  2018-01-12

10.  New Nocobactin Derivatives with Antimuscarinic Activity, Terpenibactins A-C, Revealed by Genome Mining of Nocardia terpenica IFM 0406.

Authors:  Julia Chen; Andri Frediansyah; Daniel Männle; Jan Straetener; Heike Brötz-Oesterhelt; Nadine Ziemert; Leonard Kaysser; Harald Gross
Journal:  Chembiochem       Date:  2020-04-02       Impact factor: 3.164
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