C A Curcio1, C L Millican. 1. Department of Ophthalmology, University of Alabama at Birmingham, 35294-0009, USA. curcio@vision.vsrc.uab.edu
Abstract
OBJECTIVE: To determine the distributions of basal laminar and basal linear deposits in Bruch membrane (BM) with respect to age and early age-related maculopathy (ARM). METHODS: The foveas of 41 human eyes (<60 years [n = 9]; > or =60 years [n = 32]), preserved no later than 3.5 hours post mortem, were examined using light and electron microscopy. Ten eyes met histopathologic criteria of the Alabama Age-related Macular Degeneration Grading System for early ARM. We calculated the specificity, sensitivity, and odds ratios for the association of basal laminar and basal linear deposits with early ARM. RESULTS: Both deposits occurred only in eyes older than 60 years. The highest specificities and sensitivities for early ARM were attained for eyes that had basal linear deposits or large (>125 microm) drusen, followed by eyes with any quantity of basal laminar deposits that also contained membranous debris. Eyes with ARM were 24 times more likely than age-matched control eyes to have basal linear deposits or large drusen (P = .002). CONCLUSIONS: Basal linear deposits and large drusen with membranous contents constitute different morphologic forms of the same ARM-associated lesion and may be significant for progression to late ARM.
OBJECTIVE: To determine the distributions of basal laminar and basal linear deposits in Bruch membrane (BM) with respect to age and early age-related maculopathy (ARM). METHODS: The foveas of 41 human eyes (<60 years [n = 9]; > or =60 years [n = 32]), preserved no later than 3.5 hours post mortem, were examined using light and electron microscopy. Ten eyes met histopathologic criteria of the Alabama Age-related Macular Degeneration Grading System for early ARM. We calculated the specificity, sensitivity, and odds ratios for the association of basal laminar and basal linear deposits with early ARM. RESULTS: Both deposits occurred only in eyes older than 60 years. The highest specificities and sensitivities for early ARM were attained for eyes that had basal linear deposits or large (>125 microm) drusen, followed by eyes with any quantity of basal laminar deposits that also contained membranous debris. Eyes with ARM were 24 times more likely than age-matched control eyes to have basal linear deposits or large drusen (P = .002). CONCLUSIONS:Basal linear deposits and large drusen with membranous contents constitute different morphologic forms of the same ARM-associated lesion and may be significant for progression to late ARM.
Authors: Alexander G Marneros; Douglas R Keene; Uwe Hansen; Naomi Fukai; Karen Moulton; Patrice L Goletz; Gennadiy Moiseyev; Basil S Pawlyk; Willi Halfter; Sucai Dong; Masao Shibata; Tiansen Li; Rosalie K Crouch; Peter Bruckner; Bjorn R Olsen Journal: EMBO J Date: 2003-12-11 Impact factor: 11.598
Authors: Gwenole Quellec; Stephen R Russell; Johanna M Seddon; Robyn Reynolds; Todd Scheetz; Vinit B Mahajan; Edwin M Stone; Michael D Abràmoff Journal: Invest Ophthalmol Vis Sci Date: 2011-11-25 Impact factor: 4.799
Authors: Anna C S Tan; Polina Astroz; Kunal K Dansingani; Jason S Slakter; Lawrence A Yannuzzi; Christine A Curcio; K Bailey Freund Journal: Invest Ophthalmol Vis Sci Date: 2017-04-01 Impact factor: 4.799
Authors: S Scott Whitmore; Elliott H Sohn; Kathleen R Chirco; Arlene V Drack; Edwin M Stone; Budd A Tucker; Robert F Mullins Journal: Prog Retin Eye Res Date: 2014-12-05 Impact factor: 21.198
Authors: G Malek; L V Johnson; B E Mace; P Saloupis; D E Schmechel; D W Rickman; C A Toth; P M Sullivan; C Bowes Rickman Journal: Proc Natl Acad Sci U S A Date: 2005-08-03 Impact factor: 11.205