Literature DB >> 1008546

Effect of 9-beta-D-arabinofuranosyladenine 5'-monophosphate and 9-beta-D-arabinofuranosylhypoxanthine 5'-monophosphate on experimental herpes simplex keratitis.

H E Kaufman, E D Varnell.   

Abstract

Treatment of established experimental keratitis caused by herpes simplex virus with 9-beta-d-arabinofuranosyladenine 5'-monophosphate (Ara-AMP) or 9-beta-d-arabinofuranosylhypoxanthine 5'-monophosphate (Ara-HxMP) showed that the Ara-AMP, in a concentration of 2 or 20%, had a significant effect on the keratitis but that 0.4% Ara-HxMP showed only minimal activity. Ara-AMP was also effective in the treatment of idoxuridine-resistant keratitis. No local toxicity with a high concentration (20%) of Ara-AMP was seen, but the duration of therapy was brief.

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Year:  1976        PMID： 1008546      PMCID： PMC429859          DOI： 10.1128/AAC.10.6.885

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  10 in total

1.  CORNEAL TOXICITY OF CYTOSINE ARABINOSIDE.

Authors:  H E KAUFMAN; J A CAPELLA; E D MALONEY; J E ROBBINS; G M COOPER; M H UOTILA
Journal:  Arch Ophthalmol       Date:  1964-10

2.  IDU and cytosine arabinoside in experimental herpetic keratitis.

Authors:  H E KAUFMAN; E D MALONEY
Journal:  Arch Ophthalmol       Date:  1963-05

3.  IDU therapy of herpes simplex.

Authors:  H E KAUFMAN; A B NESBURN; E D MALONEY
Journal:  Arch Ophthalmol       Date:  1962-05

4.  Clinical evaluation of trifluorothymidine in the treatment of herpes simplex corneal ulcers.

Authors:  P C Wellings; P N Awdry; F H Bors; B R Jones; D C Brown; H E Kaufman
Journal:  Am J Ophthalmol       Date:  1972-06       Impact factor: 5.258

5.  Penetration of mouse fibroblasts by the 5'-phosphate of 9-beta-D-arabinofuranosyladenine and incorporation of the nucleotide into DNA.

Authors:  W Plunkett; L Lapi; P J Ortiz; S S Cohen
Journal:  Proc Natl Acad Sci U S A       Date:  1974-01       Impact factor: 11.205

6.  A double blind clinical study of adenine arabinoside therapy of viral keratoconjunctivitis.

Authors:  D Pavan-Langston; C H Dohlman
Journal:  Am J Ophthalmol       Date:  1972-07       Impact factor: 5.258

7.  In vivo studies with antiviral agents.

Authors:  H E Kaufmann
Journal:  Ann N Y Acad Sci       Date:  1965-07-30       Impact factor: 5.691

8.  The chemotherapy of herpes iritis with adenine arabinoside and cytarabine.

Authors:  H E Kaufman; E D Ellison; W M Townsend
Journal:  Arch Ophthalmol       Date:  1970-12

9.  Viral keratitis-inhibitory effect of 9-beta-D-arabinofuranosylhypoxanthine 5'-monophosphate.

Authors:  R W Sidwell; L B Allen; J H Huffman; G R Revankar; R K Robins; R L Tolman
Journal:  Antimicrob Agents Chemother       Date:  1975-10       Impact factor: 5.191

10.  THERAPEUTIC ANTIVIRAL ACTION OF 5-TRIFLUOROMETHYL-2'-DEOXYURIDINE IN HERPES SIMPLEX KERATITIS.

Authors:  H E KAUFMAN; C HEIDELBERGER
Journal:  Science       Date:  1964-08-07       Impact factor: 47.728
  10 in total
  1 in total

1.  Iontophoretic application of adenine arabinoside monophosphate to herpes simplex virus type 1-infected hairless mouse skin.

Authors:  N H Park; L P Gangarosa; B S Kwon; J M Hill
Journal:  Antimicrob Agents Chemother       Date:  1978-10       Impact factor: 5.191
  1 in total

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