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Literature DB >> 1008541

Biological activity of netilmicin, a broad-spectrum semisynthetic aminoglycoside antibiotic.

G H Miller, G Arcieri, M J Weinstein, J A Waitz.

Abstract

Netilmicin (Sch 20569) is a new broad-spectrum semisynthetic aminoglycoside derived from sisomicin. Netilmicin was compared to gentamicin, tobramycin, and amikacin in a variety of in vitro test systems as well as in mouse protection tests. Netilmicin was found to be similar in activity to gentamicin against aminoglycoside-susceptible strains in both in vitro and in vivo tests. Netilmicin was also active against many aminoglycoside-resistant strains of gram-negative bacteria, particularly those known to possess adenylating enzymes (ANT 2') or those with a similar resistance pattern. Netilmicin was found to be markedly less toxic than gentamicin in chronic studies in cats, although gentamicin appeared less toxic in acute toxicity tests in mice. The concentrations of netilmicin and gentamicin in serum were compared in dogs after intramuscular dosing, and the pharmacokinetics including peak concentrations in serum were found to be similar.

Entities: Chemical Disease Gene Species

Mesh：

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Year: 1976 PMID： 1008541 PMCID： PMC429844 DOI： 10.1128/AAC.10.5.827

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

8 in total

1. Serum protein binding of the aminoglycoside antibiotics.

Authors: R C Gordon; C Regamey; W M Kirby
Journal: Antimicrob Agents Chemother Date: 1972-09 Impact factor: 5.191

2. Aspects of the chronic toxicity of gentamicin sulfate in cats.

Authors: J A Waitz; E L Moss; M J Weinstein
Journal: J Infect Dis Date: 1971-12 Impact factor: 5.226

3. Nosocomial infection caused by gentamicin-resistant, streptomycin-sensitive Klebsiella.

Authors: E R Noriega; R E Leibowitz; A S Richmond; E Rubinstein; S Schaefler; M S Simberkoff; J J Rahal
Journal: J Infect Dis Date: 1975-05 Impact factor: 5.226

4. Antibiotic 6640. 3. Biological studies with antibiotic 6640, a new broad-spectrum aminoglycoside antibiotic.

Authors: J A Waitz; E L Moss; E M Oden; M J Weinstein
Journal: J Antibiot (Tokyo) Date: 1970-11 Impact factor: 2.649

5. Biological activity of Sch 14342, an aminoglycoside antibiotic coproduced in the gentamicin fermentation.

Authors: J A Waitz; E L Moss; E M Oden; G H Wagman; M J Weinstein
Journal: Antimicrob Agents Chemother Date: 1972-12 Impact factor: 5.191

6. In vitro comparison of netilmicin, a semisynthetic derivative of sisomicin, and four other aminoglycoside antibiotics.

Authors: S A Kabins; C Nathan; S Cohen
Journal: Antimicrob Agents Chemother Date: 1976-07 Impact factor: 5.191

7. Bactericidal efficacy of Sch 20569 and amikacin against gentamicin-sensitive and -resistant organisms.

Authors: J J Rahal; M S Simberkoff; K Kagan; N H Moldover
Journal: Antimicrob Agents Chemother Date: 1976-04 Impact factor: 5.191

8. Activity of BB-K8 (amikacin) against clinical isolates resistant to one or more aminoglycoside antibiotics.

Authors: K E Price; T A Pursiano; M D DeFuria
Journal: Antimicrob Agents Chemother Date: 1974-02 Impact factor: 5.191

8 in total

39 in total

1. Synergy of penicillin-netilmicin combinations against enterococci including strains highly resistant to streptomycin or kanamycin.

Authors: C C Sanders
Journal: Antimicrob Agents Chemother Date: 1977-08 Impact factor: 5.191

10. In vitro studies with Sch 21420 and Sch 22591: activity in comparison with six other aminoglycosides and synergy with penicillin against enterococci.

Authors: C C Sanders; W E Sanders; R V Goering
Journal: Antimicrob Agents Chemother Date: 1978-08 Impact factor: 5.191

Biological activity of netilmicin, a broad-spectrum semisynthetic aminoglycoside antibiotic.

1. Serum protein binding of the aminoglycoside antibiotics.

2. Aspects of the chronic toxicity of gentamicin sulfate in cats.

3. Nosocomial infection caused by gentamicin-resistant, streptomycin-sensitive Klebsiella.

4. Antibiotic 6640. 3. Biological studies with antibiotic 6640, a new broad-spectrum aminoglycoside antibiotic.

5. Biological activity of Sch 14342, an aminoglycoside antibiotic coproduced in the gentamicin fermentation.

6. In vitro comparison of netilmicin, a semisynthetic derivative of sisomicin, and four other aminoglycoside antibiotics.

7. Bactericidal efficacy of Sch 20569 and amikacin against gentamicin-sensitive and -resistant organisms.

8. Activity of BB-K8 (amikacin) against clinical isolates resistant to one or more aminoglycoside antibiotics.

1. Synergy of penicillin-netilmicin combinations against enterococci including strains highly resistant to streptomycin or kanamycin.

2. In vitro studies on netilmicin, a new aminoglycoside antibiotic.

3. Pharmacokinetic study of netilmicin.

4. Correlation of netilmicin agar dilution and disk diffusion susceptibilities.

5. Netilmicin pharmacokinetics after single intravenous doses to elderly male patients.

6. Clinical pharmacology of netilmicin.

Review 7. Sisomicin, netilmicin and dibekacin. A review of their antibacterial activity and therapeutic use.

8. Antibacterial activities, nephrotoxicity, and ototoxicity of a new aminoglycoside, Win 42122-2.

9. Comparison of netilmicin with gentamicin in the therapy of experimental Escherichia coli meningitis.

10. In vitro studies with Sch 21420 and Sch 22591: activity in comparison with six other aminoglycosides and synergy with penicillin against enterococci.