Literature DB >> 10083844

Antiviral tannins from two Phyllanthus species.

K C Liu1, M T Lin, S S Lee, J F Chiou, S Ren, E J Lien.   

Abstract

Seven ellagitannins isolated from Phyllanthus myrtifolius and P. urinaria (Euphorbiaceae) have been shown, for the first time, to be active against Epstein-Barr virus DNA polymerase (EBV-DP) at the microM level. All these compounds have the same moiety of a corilagin, and differ from each other by different substitutions at C-2 and C-4 of the glucose core. SAR analysis and molecular modeling reveal that the essential pharmacophore of these tannins resides in the corilagin moiety. The outer complex carboxylic acid moieties appear to act only as auxopharmacore.

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Year:  1999        PMID： 10083844     DOI： 10.1055/s-1999-13960

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  10 in total

1.  Marked potentiation of activity of beta-lactams against methicillin-resistant Staphylococcus aureus by corilagin.

Authors:  M Shimizu; S Shiota; T Mizushima; H Ito; T Hatano; T Yoshida; T Tsuchiya
Journal:  Antimicrob Agents Chemother       Date:  2001-11       Impact factor: 5.191

2.  A potential anti-tumor herbal medicine, Corilagin, inhibits ovarian cancer cell growth through blocking the TGF-β signaling pathways.

Authors:  Luoqi Jia; Hongyan Jin; Jiayi Zhou; Lianghua Chen; Yiling Lu; Yanlin Ming; Yinhua Yu
Journal:  BMC Complement Altern Med       Date:  2013-02-15       Impact factor: 3.659

3.  Phyllanthus urinaria Induces Apoptosis in Human Osteosarcoma 143B Cells via Activation of Fas/FasL- and Mitochondria-Mediated Pathways.

Authors:  Hsin-Yi Wu; Tsu-Kung Lin; Hsiao-Mei Kuo; Ya-Ling Huang; Chia-Wei Liou; Pei-Wen Wang; Jiin-Haur Chuang; Sheng-Teng Huang
Journal:  Evid Based Complement Alternat Med       Date:  2012-02-20       Impact factor: 2.629

4.  Medicinal and ethnoveterinary remedies of hunters in Trinidad.

Authors:  C Lans; T Harper; K Georges; E Bridgewater
Journal:  BMC Complement Altern Med       Date:  2001-11-30       Impact factor: 3.659

5.  A Review of the Phytochemistry and Pharmacology of Phyllanthus urinaria L.

Authors:  Madamanchi Geethangili; Shih-Torng Ding
Journal:  Front Pharmacol       Date:  2018-10-01       Impact factor: 5.810

Review 6.  Antiviral Role of Phenolic Compounds against Dengue Virus: A Review.

Authors:  Vanessa Loaiza-Cano; Laura Milena Monsalve-Escudero; Carlos da Silva Maia Bezerra Filho; Marlen Martinez-Gutierrez; Damião Pergentino de Sousa
Journal:  Biomolecules       Date:  2020-12-24

7.  Margaritaria nobilis L.F. (Phyllanthaceae): Ethnopharmacology and Application of Computational Tools in the Annotation of Bioactive Molecules.

Authors:  Johan Carlos C Santiago; Carlos Alberto B Albuquerque; Abraão de Jesus B Muribeca; Paulo Roberto C Sá; Sônia das Graças Santa R Pamplona; Consuelo Yumiko Y E Silva; Paula Cardoso Ribera; Enéas de Andrade Fontes-Júnior; Milton Nascimento da Silva
Journal:  Metabolites       Date:  2022-07-25

8.  Inhibitory Effects of Standardized Extracts of Phyllanthus amarus and Phyllanthus urinaria and Their Marker Compounds on Phagocytic Activity of Human Neutrophils.

Authors:  Menaga Ilangkovan; Ibrahim Jantan; Hazni Falina Mohamad; Khairana Husain; Amirul Faiz Abdul Razak
Journal:  Evid Based Complement Alternat Med       Date:  2013-05-02       Impact factor: 2.629

9.  Ellagic Acid, the Active Compound of Phyllanthus urinaria, Exerts In Vivo Anti-Angiogenic Effect and Inhibits MMP-2 Activity.

Authors:  Sheng-Teng Huang; Chen-Yu Wang; Rong-Chi Yang; Hsiao-Ting Wu; Su-Hui Yang; Yung-Chi Cheng; Jong-Hwei S Pang
Journal:  Evid Based Complement Alternat Med       Date:  2011-01-11       Impact factor: 2.629

10.  Excoecarianin, Isolated from Phyllanthus urinaria Linnea, Inhibits Herpes Simplex Virus Type 2 Infection through Inactivation of Viral Particles.

Authors:  Hua-Yew Cheng; Chien-Min Yang; Ta-Chen Lin; Liang-Tzung Lin; Lien-Chai Chiang; Chun-Ching Lin
Journal:  Evid Based Complement Alternat Med       Date:  2011-05-26       Impact factor: 2.629
  10 in total

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