Literature DB >> 10081960

The folding funnel landscape for the peptide Met-enkephalin.

U H Hansmann1, Y Okamoto, J N Onuchic.   

Abstract

We study the free energy landscape of the small peptide Met-enkephalin. Our data were obtained from a generalized-ensemble Monte Carlo simulation taking the interactions among all atoms into account. We show that the free energy landscape resembles that of a funnel, indicating that this peptide is a good folder. Our work demonstrates that the energy landscape picture and folding concept, developed in the context of simplified protein models, can also be used to describe the folding in more realistic models.

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Year:  1999        PMID： 10081960     DOI： 10.1002/(sici)1097-0134(19990301)34:4<472::aid-prot7>3.0.co;2-x

Source DB:  PubMed          Journal:  Proteins        ISSN： 0887-3585


  9 in total

1.  NCAD, a database integrating the intrinsic conformational preferences of non-coded amino acids.

Authors:  Guillem Revilla-López; Juan Torras; David Curcó; Jordi Casanovas; M Isabel Calaza; David Zanuy; Ana I Jiménez; Carlos Cativiela; Ruth Nussinov; Piotr Grodzinski; Carlos Alemán
Journal:  J Phys Chem B       Date:  2010-06-03       Impact factor: 2.991

2.  A structural model of polyglutamine determined from a host-guest method combining experiments and landscape theory.

Authors:  John M Finke; Margaret S Cheung; José N Onuchic
Journal:  Biophys J       Date:  2004-09       Impact factor: 4.033

3.  Molecular mechanism for stabilizing a short helical peptide studied by generalized-ensemble simulations with explicit solvent.

Authors:  Yuji Sugita; Yuko Okamoto
Journal:  Biophys J       Date:  2005-03-04       Impact factor: 4.033

4.  Conformational study of Met-enkephalin based on the ECEPP force fields.

Authors:  Lixin Zhan; Jeff Z Y Chen; Wing-Ki Liu
Journal:  Biophys J       Date:  2006-07-07       Impact factor: 4.033

Review 5.  Exploring conformational space using a mean field technique with MOLS sampling.

Authors:  P Arun Prasad; V Kanagasabai; J Arunachalam; N Gautham
Journal:  J Biosci       Date:  2007-08       Impact factor: 1.826

6.  Multiple replica repulsion technique for efficient conformational sampling of biological systems.

Authors:  Anatoly Malevanets; Shoshana J Wodak
Journal:  Biophys J       Date:  2011-08-17       Impact factor: 4.033

Review 7.  MOLS sampling and its applications in structural biophysics.

Authors:  L Ramya; Shankaran Nehru Viji; Pandurangan Arun Prasad; Vadivel Kanagasabai; Namasivayam Gautham
Journal:  Biophys Rev       Date:  2010-11-16

8.  The free energy landscape in translational science: how can somatic mutations result in constitutive oncogenic activation?

Authors:  Chung-Jung Tsai; Ruth Nussinov
Journal:  Phys Chem Chem Phys       Date:  2014-01-21       Impact factor: 3.676

9.  The conformation of enkephalin bound to its receptor: an "elusive goal" becoming reality.

Authors:  Domenico Sanfelice; Piero A Temussi
Journal:  Front Mol Biosci       Date:  2014-10-07
  9 in total

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