Literature DB >> 10080142

Suppression of ethanol-induced apoptotic DNA fragmentation by geranylgeranylacetone in cultured guinea pig gastric mucosal cells.

T Mizushima1, S Tsutsumi, K Rokutan, T Tsuchiya.   

Abstract

The purpose of this study was to elucidate the molecular mechanism of action of geranylgeranylacetone, an antiulcer drug. Treatment with ethanol for 8 hr at the optimum concentration (7.5%) caused apoptotic DNA fragmentation in cultured guinea pig gastric mucosal cells. Pretreatment of cells with geranylgeranylacetone suppressed the DNA fragmentation in a dose-dependent manner. The maximum effect was achieved at 10(-6) M, at which concentration the drug was previously shown to induce heat-shock proteins. The suppression required an incubation period longer than 1 hr. Pretreatment of cells with low concentrations of ethanol also prevented DNA fragmentation.

Entities:  

Mesh：

Substances：

Year:  1999        PMID： 10080142     DOI： 10.1023/a:1026692920848

Source DB:  PubMed          Journal:  Dig Dis Sci        ISSN： 0163-2116            Impact factor:   3.199


  19 in total

1.  Induction of heat shock proteins and their implication in protection against ethanol-induced damage in cultured guinea pig gastric mucosal cells.

Authors:  K Nakamura; K Rokutan; N Marui; A Aoike; K Kawai
Journal:  Gastroenterology       Date:  1991-07       Impact factor: 22.682

2.  Induction of DnaK and GroEL heat shock proteins by fluoroquinolones in Escherichia coli.

Authors:  T Mizushima; M Matsuo; K Sekimizu
Journal:  Antimicrob Agents Chemother       Date:  1997-01       Impact factor: 5.191

3.  Relaxation of supercoiled DNA associated with induction of heat shock proteins in Escherichia coli.

Authors:  T Mizushima; S Natori; K Sekimizu
Journal:  Mol Gen Genet       Date:  1993-04

4.  Effects of geranylgeranylacetone on gastrointestinal secretion in rats.

Authors:  M Fujimoto; T Yamanaka; M Bessho; T Igarashi
Journal:  Eur J Pharmacol       Date:  1982-01-22       Impact factor: 4.432

5.  Tetraprenylacetone promotes healing process of ethanol-induced gastric damage in the rat.

Authors:  A Terano; J Shiga; H Mutoh; H Hiraishi; S Shiina; M Kurita; S Ota; Y Itoh; T Sugimoto
Journal:  Jpn J Pharmacol       Date:  1991-01

6.  Antiulcer effect of geranylgeranylacetone, a new acyclic polyisoprenoid on experimentally induced gastric and duodenal ulcers in rats.

Authors:  M Murakami; K Oketani; H Fujisaki; T Wakabayashi; T Ohgo
Journal:  Arzneimittelforschung       Date:  1981

7.  Advances in drug therapy for peptic ulcer disease.

Authors:  T N Pappas; S J Mulvihill; Y Goto; H T Debas
Journal:  Arch Surg       Date:  1987-04

Review 8.  Protective effects of prostaglandins against gastric mucosal damage: current knowledge and proposed mechanisms.

Authors:  T A Miller
Journal:  Am J Physiol       Date:  1983-11

9.  Protection of cultured rat gastric cells against oxidant stress by iron chelation. Role of lipid peroxidation.

Authors:  N Yajima; H Hiraishi; T Harada
Journal:  Dig Dis Sci       Date:  1995-04       Impact factor: 3.199

10.  Mild irritants prevent gastric necrosis through "adaptive cytoprotection" mediated by prostaglandins.

Authors:  A Robert; J E Nezamis; C Lancaster; J P Davis; S O Field; A J Hanchar
Journal:  Am J Physiol       Date:  1983-07
View more
  10 in total

1.  Spontaneous apoptotic DNA fragmentation in cultured guinea pig gastric mucosal cells.

Authors:  S Tsutsumi; K Rokutan; T Tsuchiya; T Mizushima
Journal:  Dig Dis Sci       Date:  2000-02       Impact factor: 3.199

2.  Protective effects of Ginkgo biloba extract on the ethanol-induced gastric ulcer in rats.

Authors:  Sheng-Hsuan Chen; Yu-Chih Liang; Jane C J Chao; Li-Hsueh Tsai; Chun-Chao Chang; Chia-Chi Wang; Shiann Pan
Journal:  World J Gastroenterol       Date:  2005-06-28       Impact factor: 5.742

Review 3.  Alcohol stress, membranes, and chaperones.

Authors:  Melinda E Tóth; László Vígh; Miklós Sántha
Journal:  Cell Stress Chaperones       Date:  2014-05       Impact factor: 3.667

4.  Oral administration of geranylgeranylacetone plus local somatothermal stimulation: a simple, effective, safe and operable preconditioning combination for conferring tolerance against ischemia-reperfusion injury in rat livers.

Authors:  Ning Fan; Guang-Shun Yang; Jun-Hua Lu; Ning Yang; Hai-Bin Zhang
Journal:  World J Gastroenterol       Date:  2005-09-28       Impact factor: 5.742

5.  Retinal ganglion cell protection with geranylgeranylacetone, a heat shock protein inducer, in a rat glaucoma model.

Authors:  Joseph Caprioli; Yoko Ishii; Jacky M K Kwong
Journal:  Trans Am Ophthalmol Soc       Date:  2003

6.  Geranylgeranylacetone protects guinea pig gastric mucosal cells from gastric stressor-induced apoptosis.

Authors:  Tatsunori Takano; Shinji Tsutsumi; Wataru Tomisato; Tatsuya Hoshino; Tomofusa Tsuchiya; Tohru Mizushima
Journal:  Dig Dis Sci       Date:  2002-07       Impact factor: 3.199

7.  Adaptive cytoprotection induced by pretreatment with ethanol protects against gastric cell damage by NSAIDs.

Authors:  Ken-Ichiro Tanaka; Kiyo Nishimoto; Wataru Tomisato; Shinji Tsutsumi; Tatsuya Hoshino; Tomofusa Tsuchiya; Tohru Mizushima
Journal:  Dig Dis Sci       Date:  2004-02       Impact factor: 3.199

8.  Maturation-associated increase in sensitivity of cultured guinea pig gastric pit cells to hydrogen peroxide.

Authors:  Wataru Tomisato; Tatsuya Hoshino; Shinji Tsutsumi; Tomofusa Tsuchiya; Tohru Mizushima
Journal:  Dig Dis Sci       Date:  2002-09       Impact factor: 3.199

9.  A role for HSP70 in protecting against indomethacin-induced gastric lesions.

Authors:  Shintaro Suemasu; Ken-Ichiro Tanaka; Takushi Namba; Tomoaki Ishihara; Takashi Katsu; Mitsuaki Fujimoto; Hiroaki Adachi; Gen Sobue; Koji Takeuchi; Akira Nakai; Tohru Mizushima
Journal:  J Biol Chem       Date:  2009-05-13       Impact factor: 5.157

10.  Effects of prostaglandin E2 on gastric irritant-induced apoptosis.

Authors:  Tatsuya Hoshino; Tatsunori Takano; Shinji Tsutsumi; Wataru Tomisato; Tomofusa Tsuchiya; Tohru Mizushima
Journal:  Dig Dis Sci       Date:  2002-10       Impact factor: 3.199
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.