B Strobino1, S Abid, M Gewitz. 1. Department of Pediatrics, New York Medical College-Westchester County Medical Center, Valhalla, New York, USA.
Abstract
OBJECTIVE: The purpose of this study was to determine whether maternal Lyme disease increases the risk of congenital heart defect. STUDY DESIGN: This retrospective case-control study was carried out at a medical center in a suburban area where Lyme disease is endemic. Case patients comprised 796 children with a diagnosis of congenital cardiac anomaly. Control subjects comprised 704 children without cardiac defects selected from the records of the same pediatric cardiology service. Maternal histories were obtained through a mailed questionnaire survey. Unconditional logistic regression analyses examined the relationship between a history of preconception and prenatal clinical Lyme disease or tick bite and case or control status. RESULTS: There was no association between congenital heart defect and maternal tick bite (adjusted odds ratio 1.1, 95% confidence interval 0.5-2.5) or maternal Lyme disease within 3 months of conception or during pregnancy (adjusted odds ratio 0.9; 95% confidence interval 0.2-3.6). CONCLUSION: A woman who has been bitten by a tick or is treated for Lyme disease during or before pregnancy is not at increased risk for giving birth to a child with a congenital heart defect.
OBJECTIVE: The purpose of this study was to determine whether maternal Lyme disease increases the risk of congenital heart defect. STUDY DESIGN: This retrospective case-control study was carried out at a medical center in a suburban area where Lyme disease is endemic. Case patients comprised 796 children with a diagnosis of congenital cardiac anomaly. Control subjects comprised 704 children without cardiac defects selected from the records of the same pediatric cardiology service. Maternal histories were obtained through a mailed questionnaire survey. Unconditional logistic regression analyses examined the relationship between a history of preconception and prenatal clinical Lyme disease or tick bite and case or control status. RESULTS: There was no association between congenital heart defect and maternal tick bite (adjusted odds ratio 1.1, 95% confidence interval 0.5-2.5) or maternal Lyme disease within 3 months of conception or during pregnancy (adjusted odds ratio 0.9; 95% confidence interval 0.2-3.6). CONCLUSION: A woman who has been bitten by a tick or is treated for Lyme disease during or before pregnancy is not at increased risk for giving birth to a child with a congenital heart defect.
Authors: Vera Maraspin; Lara Lusa; Tanja Blejec; Eva Ružić-Sabljić; Maja Pohar Perme; Franc Strle Journal: J Clin Med Date: 2020-07-24 Impact factor: 4.241