Literature DB >> 10072356

The INK4A/ARF locus and its two gene products.

N E Sharpless1, R A DePinho.   

Abstract

The INK4A/ARF locus on chromosome 9 is one of the sites mutated most frequently in human cancer. Two genes comprising overlapping reading frames encoding p16(INK4a) and p19(ARF) have been discovered at this locus and, remarkably, both play an important role in regulating cell growth, survival and senescence.

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Year:  1999        PMID： 10072356     DOI： 10.1016/s0959-437x(99)80004-5

Source DB:  PubMed          Journal:  Curr Opin Genet Dev        ISSN： 0959-437X            Impact factor:   5.578


  143 in total

1.  p19ARF targets certain E2F species for degradation.

Authors:  F Martelli; T Hamilton; D P Silver; N E Sharpless; N Bardeesy; M Rokas; R A DePinho; D M Livingston; S R Grossman
Journal:  Proc Natl Acad Sci U S A       Date:  2001-03-27       Impact factor: 11.205

Review 2.  Cell cycle checkpoints and their inactivation in human cancer.

Authors:  M Molinari
Journal:  Cell Prolif       Date:  2000-10       Impact factor: 6.831

3.  Extensively overlapping reading frames in a second mammalian gene.

Authors:  M Kozak
Journal:  EMBO Rep       Date:  2001-09       Impact factor: 8.807

4.  Role of p14(ARF) in replicative and induced senescence of human fibroblasts.

Authors:  W Wei; R M Hemmer; J M Sedivy
Journal:  Mol Cell Biol       Date:  2001-10       Impact factor: 4.272

5.  New approaches to the biology of melanoma: a workshop of the National Institutes of Health Pathology B Study Section.

Authors:  Meenhard Herlyn; Martin Padarathsingh; Lynda Chin; Mary Hendrix; Dorothea Becker; Mark Nelson; Yves DeClerck; James McCarthy; Suresh Mohla
Journal:  Am J Pathol       Date:  2002-11       Impact factor: 4.307

6.  Human papillomavirus type 16 E7 oncoprotein binds and inactivates growth-inhibitory insulin-like growth factor binding protein 3.

Authors:  B Mannhardt; S A Weinzimer; M Wagner; M Fiedler; P Cohen; P Jansen-Dürr; W Zwerschke
Journal:  Mol Cell Biol       Date:  2000-09       Impact factor: 4.272

Review 7.  Bmi1, stem cells, and senescence regulation.

Authors:  In-Kyung Park; Sean J Morrison; Michael F Clarke
Journal:  J Clin Invest       Date:  2004-01       Impact factor: 14.808

8.  Invasive melanoma in Cdk4-targeted mice.

Authors:  R Sotillo; J F García; S Ortega; J Martin; P Dubus; M Barbacid; M Malumbres
Journal:  Proc Natl Acad Sci U S A       Date:  2001-10-23       Impact factor: 11.205

9.  Alterations of the Notch pathway in lung cancer.

Authors:  Britta Westhoff; Ivan N Colaluca; Giovanni D'Ario; Maddalena Donzelli; Daniela Tosoni; Sara Volorio; Giuseppe Pelosi; Lorenzo Spaggiari; Giovanni Mazzarol; Giuseppe Viale; Salvatore Pece; Pier Paolo Di Fiore
Journal:  Proc Natl Acad Sci U S A       Date:  2009-12-10       Impact factor: 11.205

10.  Combined modulation of polycomb and trithorax genes rejuvenates β cell replication.

Authors:  Josie X Zhou; Sangeeta Dhawan; Hualin Fu; Emily Snyder; Rita Bottino; Sharmistha Kundu; Seung K Kim; Anil Bhushan
Journal:  J Clin Invest       Date:  2013-11       Impact factor: 14.808
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