Literature DB >> 10072355

Ras caught in another affair: the exchange factors for Ral.

R M Wolthuis1, J L Bos.   

Abstract

The Ral guanine nucleotide exchange factors are direct targets of Ras, providing a mechanism for Ral activation by extracellular signals. In addition, Ral can be activated by a Ras-independent pathway. Ral guanine nucleotide exchange factors contribute to cellular transformation induced by oncogenic Ras through an Erk-independent mechanism which may involve activation of transcription.

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Year:  1999        PMID： 10072355     DOI： 10.1016/s0959-437x(99)80016-1

Source DB:  PubMed          Journal:  Curr Opin Genet Dev        ISSN： 0959-437X            Impact factor:   5.578


  37 in total

1.  Ral GTPases contribute to regulation of cyclin D1 through activation of NF-kappaB.

Authors:  D O Henry; S A Moskalenko; K J Kaur; M Fu; R G Pestell; J H Camonis; M A White
Journal:  Mol Cell Biol       Date:  2000-11       Impact factor: 4.272

2.  Regulation of the Forkhead transcription factor AFX by Ral-dependent phosphorylation of threonines 447 and 451.

Authors:  N D De Ruiter; B M Burgering; J L Bos
Journal:  Mol Cell Biol       Date:  2001-12       Impact factor: 4.272

3.  RalA activation at nascent lamellipodia of epidermal growth factor-stimulated Cos7 cells and migrating Madin-Darby canine kidney cells.

Authors:  Akiyuki Takaya; Yusuke Ohba; Kazuo Kurokawa; Michiyuki Matsuda
Journal:  Mol Biol Cell       Date:  2004-03-19       Impact factor: 4.138

4.  Analysis of cytogenetic aberrations in sporadic vestibular schwannoma by comparative genomic hybridization.

Authors:  Dimitrios Koutsimpelas; Uwe Felmeden; Wolf J Mann; Jürgen Brieger
Journal:  J Neurooncol       Date:  2010-09-26       Impact factor: 4.130

5.  R-Ras regulates exocytosis by Rgl2/Rlf-mediated activation of RalA on endosomes.

Authors:  Akiyuki Takaya; Takahiro Kamio; Michitaka Masuda; Naoki Mochizuki; Hirofumi Sawa; Mami Sato; Kazuo Nagashima; Akiko Mizutani; Akira Matsuno; Etsuko Kiyokawa; Michiyuki Matsuda
Journal:  Mol Biol Cell       Date:  2007-03-07       Impact factor: 4.138

6.  Cathepsin L increased level upon Ras mutants expression: the role of p38 and p44/42 MAPK signaling pathways.

Authors:  Lorena Urbanelli; Francesco Trivelli; Luisa Ercolani; Eleonora Sementino; Alessandro Magini; Brunella Tancini; Raffaella Franceschini; Carla Emiliani
Journal:  Mol Cell Biochem       Date:  2010-06-04       Impact factor: 3.396

7.  K-RasG12D-induced T-cell lymphoblastic lymphoma/leukemias harbor Notch1 mutations and are sensitive to gamma-secretase inhibitors.

Authors:  Thomas Kindler; Melanie G Cornejo; Claudia Scholl; Jianing Liu; Dena S Leeman; J Erika Haydu; Stefan Fröhling; Benjamin H Lee; D Gary Gilliland
Journal:  Blood       Date:  2008-07-28       Impact factor: 22.113

8.  Rnd proteins function as RhoA antagonists by activating p190 RhoGAP.

Authors:  Krister Wennerberg; Marie-Annick Forget; Shawn M Ellerbroek; William T Arthur; Keith Burridge; Jeffrey Settleman; Channing J Der; Steen H Hansen
Journal:  Curr Biol       Date:  2003-07-01       Impact factor: 10.834

Review 9.  Cellular FLICE-like inhibitory protein (C-FLIP): a novel target for cancer therapy.

Authors:  Ahmad R Safa; Travis W Day; Ching-Huang Wu
Journal:  Curr Cancer Drug Targets       Date:  2008-02       Impact factor: 3.428

10.  A constitutive decay element promotes tumor necrosis factor alpha mRNA degradation via an AU-rich element-independent pathway.

Authors:  Georg Stoecklin; Min Lu; Bernd Rattenbacher; Christoph Moroni
Journal:  Mol Cell Biol       Date:  2003-05       Impact factor: 4.272
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