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Literature DB >> 10071086

Allelotyping of acute myelogenous leukemia: loss of heterozygosity at 7q31.1 (D7S486) and q33-34 (D7S498, D7S505).

M Koike¹, T Tasaka, S Spira, N Tsuruoka, H P Koeffler.

Abstract

Loss of a whole chromosome 7(-7) or a deletion of the long arm of chromosome 7 del(7q) occurs frequently in many types of primary cancers including cases of acute myelogenous leukemia (AML). We analyzed for loss of heterozygosity (LOH) of chromosome arm 7q in 26 AML cases using a set of 15 microsatellite markers in order to begin to determine the location of putative tumor suppressor genes (TSG) important to this disease. Seven samples (27%) showed LOH at one or more loci on chromosome 7q. We identified the smallest commonly deleted regions to be at 7q31.1 (D7S486) and 7q33-34 (D7S498, D7S505) suggesting that alterations of a TSG in each region have an important role in de novo AML.

Entities: Disease

Mesh：

Year: 1999 PMID： 10071086 DOI： 10.1016/s0145-2126(98)00159-3

Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156

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Cited

10 in total

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4. The tumor suppressor protein HBP1 is a novel c-myc-binding protein that negatively regulates c-myc transcriptional activity.

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Journal: J Biol Chem Date: 2009-12-11 Impact factor: 5.157

Allelotyping of acute myelogenous leukemia: loss of heterozygosity at 7q31.1 (D7S486) and q33-34 (D7S498, D7S505).

1. A positive feedback loop between Pim-1 kinase and HBP1 transcription factor contributes to hydrogen peroxide-induced premature senescence and apoptosis.

2. HMG box transcriptional repressor HBP1 maintains a proliferation barrier in differentiated liver tissue.

3. Negative regulation of the Wnt-beta-catenin pathway by the transcriptional repressor HBP1.

4. The tumor suppressor protein HBP1 is a novel c-myc-binding protein that negatively regulates c-myc transcriptional activity.

5. Mutations in the ST7/RAY1/HELG locus rarely occur in primary colorectal, gastric, and hepatocellular carcinomas.

6. Expression of tumor related gene NAG6 in gastric cancer and restriction fragment length polymorphism analysis.

Review 7. The HMG box transcription factor HBP1: a cell cycle inhibitor at the crossroads of cancer signaling pathways.

8. HBP1 repression of the p47phox gene: cell cycle regulation via the NADPH oxidase.

9. TESTIN Induces Rapid Death and Suppresses Proliferation in Childhood B Acute Lymphoblastic Leukaemia Cells.

Review 10. The Role of Testin in Human Cancers.