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Literature DB >> 10049909

The specific genes for lantibiotic mutacin II biosynthesis in Streptococcus mutans T8 are clustered and can be transferred en bloc.

Abstract

Mutacin II is a ribosomally synthesized peptide lantibiotic produced by group II Streptococcus mutans. DNA sequencing has revealed that the mutacin II biosynthetic gene cluster consists of seven specific open reading frames: a regulator (mutR), the prepromutacin structural gene (mutA), a modifying protein (mutM), an ABC transporter (mutT), and an immunity cluster (mutFEG). Transformations of a non-mutacin-producing strain, S. mutans UA159, and a mutacin I-producing strain, S. mutans UA140, with chromosomal DNA from S. mutans T8 with an aphIII marker inserted upstream of the mutacin II structural gene yielded transformants producing mutacin II and mutacins I and II, respectively.

Entities: Chemical Species

Mesh：

Substances：
Bacteriocins
mutacin II

Year: 1999 PMID： 10049909 PMCID： PMC91190

Source DB: PubMed Journal: Appl Environ Microbiol ISSN： 0099-2240 Impact factor: 4.792

30 in total

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Journal: J Bacteriol Date: 1992-06 Impact factor: 3.490

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Journal: Eur J Biochem Date: 1992-03-15

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Journal: Gene Date: 1989-12-07 Impact factor: 3.688

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Authors: P Trieu-Cuot; P Courvalin
Journal: Gene Date: 1983-09 Impact factor: 3.688

5. Conjugal transfer in Lactococcus lactis of a 68-kilobase-pair chromosomal fragment containing the structural gene for the peptide bacteriocin nisin.

Authors: T Gireesh; B E Davidson; A J Hillier
Journal: Appl Environ Microbiol Date: 1992-05 Impact factor: 4.792

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Authors: W Liu; J N Hansen
Journal: J Bacteriol Date: 1991-11 Impact factor: 3.490

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Journal: Can J Microbiol Date: 1990-02 Impact factor: 2.419

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Journal: Appl Environ Microbiol Date: 1998-07 Impact factor: 4.792

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Journal: J Biol Chem Date: 1988-11-05 Impact factor: 5.157

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Authors: N Schnell; K D Entian; U Schneider; F Götz; H Zähner; R Kellner; G Jung
Journal: Nature Date: 1988-05-19 Impact factor: 49.962

32 in total

1. Role of the single regulator MrsR1 and the two-component system MrsR2/K2 in the regulation of mersacidin production and immunity.

Authors: André Guder; Tim Schmitter; Imke Wiedemann; Hans-Georg Sahl; Gabriele Bierbaum
Journal: Appl Environ Microbiol Date: 2002-01 Impact factor: 4.792

2. Lantibiotic biosynthesis: interactions between prelacticin 481 and its putative modification enzyme, LctM.

Authors: P Uguen; J P Le Pennec; A Dufour
Journal: J Bacteriol Date: 2000-09 Impact factor: 3.490

3. IS1675, a novel lactococcal insertion element, forms a transposon-like structure including the lacticin 481 lantibiotic operon.

Authors: A Dufour; A Rincé; P Uguen; J P Le Pennec
Journal: J Bacteriol Date: 2000-10 Impact factor: 3.490

4. Characterization of a new operon, as-48EFGH, from the as-48 gene cluster involved in immunity to enterocin AS-48.

Authors: Marta Diaz; Eva Valdivia; Manuel Martínez-Bueno; Matilde Fernández; Andrés Santos Soler-González; Hilario Ramírez-Rodrigo; Mercedes Maqueda
Journal: Appl Environ Microbiol Date: 2003-02 Impact factor: 4.792

5. Autoregulation of lantibiotic bovicin HJ50 biosynthesis by the BovK-BovR two-component signal transduction system in Streptococcus bovis HJ50.

Authors: Jianqiang Ni; Kunling Teng; Gang Liu; Caixia Qiao; Liandong Huan; Jin Zhong
Journal: Appl Environ Microbiol Date: 2010-11-12 Impact factor: 4.792

10. Cooperative transport between NukFEG and NukH in immunity against the lantibiotic nukacin ISK-1 produced by Staphylococcus warneri ISK-1.

Authors: Ken-ichi Okuda; Yuji Aso; Jiro Nakayama; Kenji Sonomoto
Journal: J Bacteriol Date: 2007-10-19 Impact factor: 3.490