Literature DB >> 10049291

Declining concentrations of dihydroartemisinin in plasma during 5-day oral treatment with artesunate for Falciparum malaria.

N X Khanh1, P J de Vries, L D Ha, C J van Boxtel, R Koopmans, P A Kager.   

Abstract

Six patients with uncomplicated falciparum malaria received artesunate for 5 days. Plasma concentrations of artesunate and dihydroartemisinin were determined by high-performance liquid chromatography with electrochemical detection. The concentrations of dihydroartemisinin in plasma 2 h after a dose showed a time-dependent decline. Concentrations of artesunate in plasma especially after the last dose, were very low. Despite this, all patients responded with a fast recovery.

Entities:  

Mesh：

Substances：

Year:  1999        PMID： 10049291      PMCID： PMC89184     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  11 in total

1.  Pharmacokinetics of oral artesunate in children with moderately severe Plasmodium falciparum malaria.

Authors:  D B Bethell; P Teja-Isavadharm; X T Cao; T T Pham; T T Ta; T N Tran; T T Nguyen; T P Pham; D Kyle; N P Day; N J White
Journal:  Trans R Soc Trop Med Hyg       Date:  1997 Mar-Apr       Impact factor: 2.184

2.  Pharmacokinetics of artemisinin and artesunate after oral administration in healthy volunteers.

Authors:  A Benakis; M Paris; L Loutan; C T Plessas; S T Plessas
Journal:  Am J Trop Med Hyg       Date:  1997-01       Impact factor: 2.345

3.  Effect of food intake on pharmacokinetics of oral artemisinin in healthy Vietnamese subjects.

Authors:  T K Dien; P J de Vries; N X Khanh; R Koopmans; L N Binh; D D Duc; P A Kager; C J van Boxtel
Journal:  Antimicrob Agents Chemother       Date:  1997-05       Impact factor: 5.191

4.  Single day mefloquine-artesunate combination in the treatment of multi-drug resistant falciparum malaria.

Authors:  C Luxemburger; F O ter Kuile; F Nosten; G Dolan; J H Bradol; L Phaipun; T Chongsuphajaisiddhi; N J White
Journal:  Trans R Soc Trop Med Hyg       Date:  1994 Mar-Apr       Impact factor: 2.184

5.  Selective high-performance liquid chromatographic determination of artesunate and alpha- and beta-dihydroartemisinin in patients with falciparum malaria.

Authors:  K T Batty; T M Davis; L T Thu; T Q Binh; T K Anh; K F Ilett
Journal:  J Chromatogr B Biomed Appl       Date:  1996-03-03

Review 6.  Clinical pharmacology and therapeutic potential of artemisinin and its derivatives in the treatment of malaria.

Authors:  P J de Vries; T K Dien
Journal:  Drugs       Date:  1996-12       Impact factor: 9.546

7.  [Pharmacokinetics of dihydroqinghaosu in human volunteers and comparison with qinghaosu].

Authors:  K C Zhao; Z Y Song
Journal:  Yao Xue Xue Bao       Date:  1993

8.  Treatment of multidrug-resistant Plasmodium falciparum malaria with 3-day artesunate-mefloquine combination.

Authors:  F Nosten; C Luxemburger; F O ter Kuile; C Woodrow; J P Eh; T Chongsuphajaisiddhi; N J White
Journal:  J Infect Dis       Date:  1994-10       Impact factor: 5.226

9.  Randomised trial of artesunate and mefloquine alone and in sequence for acute uncomplicated falciparum malaria.

Authors:  S Looareesuwan; C Viravan; S Vanijanonta; P Wilairatana; P Suntharasamai; P Charoenlarp; K Arnold; D Kyle; C Canfield; K Webster
Journal:  Lancet       Date:  1992-04-04       Impact factor: 79.321

10.  Multiple dose pharmacokinetics of oral artemisinin and comparison of its efficacy with that of oral artesunate in falciparum malaria patients.

Authors:  M Hassan Alin; M Ashton; C M Kihamia; G J Mtey; A Björkman
Journal:  Trans R Soc Trop Med Hyg       Date:  1996 Jan-Feb       Impact factor: 2.184
View more
  23 in total

Review 1.  Pharmacokinetic interactions of antimalarial agents.

Authors:  P T Giao; P J de Vries
Journal:  Clin Pharmacokinet       Date:  2001       Impact factor: 6.447

2.  A comparison of oral artesunate and artemether antimalarial bioactivities in acute falciparum malaria.

Authors:  Y Suputtamongkol; P N Newton; B Angus; P Teja-Isavadharm; D Keeratithakul; M Rasameesoraj; S Pukrittayakamee; N J White
Journal:  Br J Clin Pharmacol       Date:  2001-12       Impact factor: 4.335

3.  In vitro evidence for auto-induction of artemisinin metabolism in the rat.

Authors:  S Gupta; U S Svensson; M Ashton
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2001 Jul-Sep       Impact factor: 2.441

4.  Antimalarial bioavailability and disposition of artesunate in acute falciparum malaria.

Authors:  P Newton; Y Suputtamongkol; P Teja-Isavadharm; S Pukrittayakamee; V Navaratnam; I Bates; N White
Journal:  Antimicrob Agents Chemother       Date:  2000-04       Impact factor: 5.191

5.  Pharmacokinetics of chlorproguanil, dapsone, artesunate and their major metabolites in patients during treatment of acute uncomplicated Plasmodium falciparum malaria.

Authors:  Ann K Miller; Nibedita Bandyopadhyay; Daniel G Wootton; Stephan Duparc; Paula L Kirby; Peter A Winstanley; Stephen A Ward
Journal:  Eur J Clin Pharmacol       Date:  2009-06-11       Impact factor: 2.953

6.  Population pharmacokinetics of artesunate and dihydroartemisinin following single- and multiple-dosing of oral artesunate in healthy subjects.

Authors:  Beesan Tan; Himanshu Naik; In-Jin Jang; Kyung-Sang Yu; Lee E Kirsch; Chang-Sik Shin; J Carl Craft; Lawrence Fleckenstein
Journal:  Malar J       Date:  2009-12-18       Impact factor: 2.979

7.  Disposition of artesunate and dihydroartemisinin after administration of artesunate suppositories in children from Papua New Guinea with uncomplicated malaria.

Authors:  Harin A Karunajeewa; Kenneth F Ilett; Kitiya Dufall; Adedayo Kemiki; Moses Bockarie; Michael P Alpers; P Hugh Barrett; Paolo Vicini; Timothy M E Davis
Journal:  Antimicrob Agents Chemother       Date:  2004-08       Impact factor: 5.191

8.  Absence of time-dependent artesunate pharmacokinetics in healthy subjects during 5-day oral administration.

Authors:  L T Diem Thuy; L Ngoc Hung; P T Danh; K Na-Bangchang
Journal:  Eur J Clin Pharmacol       Date:  2008-07-04       Impact factor: 2.953

9.  Pharmacokinetics of dihydroartemisinin following oral artesunate treatment of pregnant women with acute uncomplicated falciparum malaria.

Authors:  R McGready; K Stepniewska; S A Ward; T Cho; G Gilveray; S Looareesuwan; N J White; F Nosten
Journal:  Eur J Clin Pharmacol       Date:  2006-03-22       Impact factor: 2.953

10.  Tolerability and pharmacokinetics of non-fixed and fixed combinations of artesunate and amodiaquine in Malaysian healthy normal volunteers.

Authors:  Visweswaran Navaratnam; Surash Ramanathan; Mohd Suhaimi Ab Wahab; Gan Siew Hua; Sharif Mahsufi Mansor; Jean-René Kiechel; Michel Vaillant; Walter R J Taylor; Piero Olliaro
Journal:  Eur J Clin Pharmacol       Date:  2009-04-30       Impact factor: 2.953
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.