Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Ion channel modulation as the basis for general anesthesia.

Literature DB >> 10049141

Ion channel modulation as the basis for general anesthesia.

T Narahashi¹, G L Aistrup, J M Lindstrom, W Marszalec, K Nagata, F Wang, J Z Yeh.

Abstract

(1) Modulation of the function of the GABA(A) and neuronal nicotinic acetylcholine receptor channels caused by general anesthetics and modulation of the GABA(A) receptor-channel by halothane, enflurane, isoflurane, and n-octanol was channel state-dependent. (3) Halothane modulation of the GABA(A) receptor was independent of subunits, but n-octanol modulation was subunit-dependent. (4) Ethanol at 30-100 microM was very potent in accelerating the desensitization of currents induced by acetylcholine. (5) The ethanol modulation was subunit- and state-dependent, occurring in the alpha3beta4 combination but only weakly in the alpha3beta2 combination. (6) In contrast, halothane at 430 microM (approximately 1 MAC) potently suppressed ACh-induced currents in the alpha3beta2 subunit combination.

Entities: Chemical

Mesh：

Substances：

Year: 1998 PMID： 10049141 DOI： 10.1016/s0378-4274(98)00184-2

Source DB: PubMed Journal: Toxicol Lett ISSN： 0378-4274 Impact factor: 4.372

Keyword Cloud
Cited

8 in total

1. Two-photon imaging of cerebral hemodynamics and neural activity in awake and anesthetized marmosets.

Authors: Thom P Santisakultarm; Calvin J Kersbergen; Daryl K Bandy; David C Ide; Sang-Ho Choi; Afonso C Silva
Journal: J Neurosci Methods Date: 2016-07-05 Impact factor: 2.390

2. Protein crystallography under xenon and nitrous oxide pressure: comparison with in vivo pharmacology studies and implications for the mechanism of inhaled anesthetic action.

Authors: Nathalie Colloc'h; Jana Sopkova-de Oliveira Santos; Pascal Retailleau; Denis Vivarès; Françoise Bonneté; Béatrice Langlois d'Estainto; Bernard Gallois; Alain Brisson; Jean-Jacques Risso; Marc Lemaire; Thierry Prangé; Jacques H Abraini
Journal: Biophys J Date: 2006-10-06 Impact factor: 4.033

3. Inhalational anesthetics disrupt postsynaptic density protein-95, Drosophila disc large tumor suppressor, and zonula occludens-1 domain protein interactions critical to action of several excitatory receptor channels related to anesthesia.

Authors: Feng Tao; Qiang Chen; Yuko Sato; John Skinner; Pei Tang; Roger A Johns
Journal: Anesthesiology Date: 2015-04 Impact factor: 7.892

Ion channel modulation as the basis for general anesthesia.

1. Two-photon imaging of cerebral hemodynamics and neural activity in awake and anesthetized marmosets.

2. Protein crystallography under xenon and nitrous oxide pressure: comparison with in vivo pharmacology studies and implications for the mechanism of inhaled anesthetic action.

3. Inhalational anesthetics disrupt postsynaptic density protein-95, Drosophila disc large tumor suppressor, and zonula occludens-1 domain protein interactions critical to action of several excitatory receptor channels related to anesthesia.

4. Electrophysiological diversity of the dorsal raphe cells across the sleep-wake cycle of the rat.

5. Isoflurane-induced caspase-3 activation is dependent on cytosolic calcium and can be attenuated by memantine.

6. General anesthetic octanol and related compounds activate wild-type and delF508 cystic fibrosis chloride channels.

7. Inhibition of cAMP-phosphodiesterase 4 (PDE4) potentiates the anesthetic effects of Isoflurane in mice.

8. GABA_A Receptor/STEP61 Signaling Pathway May Be Involved in Emulsified Isoflurane Anesthesia in Rats.