Literature DB >> 10049061

The role of TEL fusion genes in pediatric leukemias.

J E Rubnitz1, C H Pui, J R Downing.   

Abstract

The TEL and AML1 genes are common targets of chromosomal translocations in hematopoietic malignancies. The TEL-AML1 fusion gene, created by the t(12;21), is the most common genetic alteration in childhood acute lymphoblastic leukemia and is associated with a favorable outcome. This review summarizes the roles of the TEL and AML1 proteins in hematopoiesis, the potential transforming mechanisms of TEL fusion proteins, and the clinical significance of the TEL-AML1 fusion.

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Year:  1999        PMID： 10049061     DOI： 10.1038/sj.leu.2401258

Source DB:  PubMed          Journal:  Leukemia        ISSN： 0887-6924            Impact factor:   11.528


  12 in total

1.  Polymerization of the SAM domain of TEL in leukemogenesis and transcriptional repression.

Authors:  C A Kim; M L Phillips; W Kim; M Gingery; H H Tran; M A Robinson; S Faham; J U Bowie
Journal:  EMBO J       Date:  2001-08-01       Impact factor: 11.598

2.  The t(1;12)(q21;p13) translocation of human acute myeloblastic leukemia results in a TEL-ARNT fusion.

Authors:  F Salomon-Nguyen; V Della-Valle; M Mauchauffe; M Busson-Le Coniat; J Ghysdael; R Berger; O A Bernard
Journal:  Proc Natl Acad Sci U S A       Date:  2000-06-06       Impact factor: 11.205

3.  Genomic analysis of fibrolamellar hepatocellular carcinoma.

Authors:  Lei Xu; Florette K Hazard; Anne-Flore Zmoos; Nadine Jahchan; Hassan Chaib; Phillip M Garfin; Arun Rangaswami; Michael P Snyder; Julien Sage
Journal:  Hum Mol Genet       Date:  2014-08-13       Impact factor: 6.150

4.  MN1-TEL myeloid oncoprotein expressed in multipotent progenitors perturbs both myeloid and lymphoid growth and causes T-lymphoid tumors in mice.

Authors:  Hiroyuki Kawagoe; Gerard C Grosveld
Journal:  Blood       Date:  2005-08-04       Impact factor: 22.113

5.  Small ubiquitin-like modifier conjugation regulates nuclear export of TEL, a putative tumor suppressor.

Authors:  Lauren D Wood; Brenda J Irvin; Giuseppina Nucifora; K Scott Luce; Scott W Hiebert
Journal:  Proc Natl Acad Sci U S A       Date:  2003-03-07       Impact factor: 11.205

6.  Down's syndrome and acute lymphoblastic leukaemia: clinical features and response to treatment.

Authors:  J M Chessells; G Harrison; S M Richards; C C Bailey; F G Hill; B E Gibson; I M Hann
Journal:  Arch Dis Child       Date:  2001-10       Impact factor: 3.791

7.  The ETS factor TEL2 is a hematopoietic oncoprotein.

Authors:  Cintia Carella; Mark Potter; Jacqueline Bonten; Jerold E Rehg; Geoffrey Neale; Gerard C Grosveld
Journal:  Blood       Date:  2005-10-18       Impact factor: 22.113

8.  Conditional MN1-TEL knock-in mice develop acute myeloid leukemia in conjunction with overexpression of HOXA9.

Authors:  Hiroyuki Kawagoe; Gerard C Grosveld
Journal:  Blood       Date:  2005-08-16       Impact factor: 22.113

9.  Profiling gene mutations, translocations, and multidrug resistance in pediatric acute lymphoblastic leukemia: a step forward to personalizing medicine.

Authors:  Alphy Rose-James; R Shiji; P Kusumakumary; Manjusha Nair; Suraj K George; T T Sreelekha
Journal:  Med Oncol       Date:  2016-07-23       Impact factor: 3.064

10.  Native interface of the SAM domain polymer of TEL.

Authors:  Hoang H Tran; Chongwoo A Kim; Salem Faham; Marie-Claire Siddall; James U Bowie
Journal:  BMC Struct Biol       Date:  2002-08-22
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