Literature DB >> 10048179

Gliclazide.

M Parvez1, M S Arayne, M K Zaman, N Sultana.   

Abstract

The crystal structure of gliclazide, N-[(perhydrocyclopenta [c]pyrrol-2-yl)aminocarbonyl]-p-toluenesulfonamide, C15H21B3O3S, a second-generation oral hypoglycemic agent, contains discrete molecules with normal molecular dimensions. Both of the five-membered fused rings adopt envelope conformations. The molecules are linked into chains by intermolecular hydrogen bonds involving amino-H atoms, with N...O separations of 2.967 (3) and 2.949 (3) A.

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Year:  1999        PMID: 10048179     DOI: 10.1107/s0108270198009883

Source DB:  PubMed          Journal:  Acta Crystallogr C        ISSN: 0108-2701            Impact factor:   1.172


  2 in total

1.  Gliclazide impurity F: N-[(perhydro-cyclo-penta-[c]pyrrol-2-yl)amino-carbon-yl]-o-toluene-sulfonamide.

Authors:  Di Wu; Xueyuan Wang; Dongying Pang; Wei Su; Yan Sun
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-01-18

Review 2.  Solubility Enhancement of Antidiabetic Drugs Using a Co-Crystallization Approach.

Authors:  Eustina Batisai
Journal:  ChemistryOpen       Date:  2021-12       Impact factor: 2.911

  2 in total

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