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Literature DB >> 10047530

Functions of gelsolin: motility, signaling, apoptosis, cancer.

Abstract

Several new members of the gelsolin family have been discovered in the past year. Determination of the structure of gelsolin and identification of lysophosphatidic acid as a negative regulator provide novel functional insights. Gelsolin is an obligate downstream effector of Rac for motility in dermal fibroblasts, regulates phosphoinositide signaling pathways and ion channel function in vivo, and acts as both a regulator and effector of apoptosis.

Entities: Chemical Disease Gene Species

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Year: 1999 PMID： 10047530 DOI： 10.1016/s0955-0674(99)80012-x

Source DB: PubMed Journal: Curr Opin Cell Biol ISSN： 0955-0674 Impact factor: 8.382

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Cited

90 in total

1. Voltage-dependent sodium channel function is regulated through membrane mechanics.

Authors: A Shcherbatko; F Ono; G Mandel; P Brehm
Journal: Biophys J Date: 1999-10 Impact factor: 4.033

2. Equilibria and kinetics of folding of gelsolin domain 2 and mutants involved in familial amyloidosis-Finnish type.

Authors: R L Isaacson; A G Weeds; A R Fersht
Journal: Proc Natl Acad Sci U S A Date: 1999-09-28 Impact factor: 11.205

3. Mitogen-activated protein kinase phosphatase is required for genotoxic stress relief in Arabidopsis.

Authors: R Ulm; E Revenkova; G P di Sansebastiano; N Bechtold; J Paszkowski
Journal: Genes Dev Date: 2001-03-15 Impact factor: 11.361

4. VASP protects actin filaments from gelsolin: an in vitro study with implications for platelet actin reorganizations.

Authors: E L Bearer; J M Prakash; R D Manchester; P G Allen
Journal: Cell Motil Cytoskeleton Date: 2000-12

5. Villin enhances hepatocyte growth factor-induced actin cytoskeleton remodeling in epithelial cells.

Authors: Rafika Athman; Daniel Louvard; Sylvie Robine
Journal: Mol Biol Cell Date: 2003-08-22 Impact factor: 4.138

6. Adaptive differences in the structure and macromolecular compositions of the air and water corneas of the "four-eyed" fish (Anableps anableps).

Authors: Shivalingappa K Swamynathan; Mary A Crawford; W Gerald Robison; Jyotshnabala Kanungo; Joram Piatigorsky
Journal: FASEB J Date: 2003-11 Impact factor: 5.191

Functions of gelsolin: motility, signaling, apoptosis, cancer.

1. Voltage-dependent sodium channel function is regulated through membrane mechanics.

2. Equilibria and kinetics of folding of gelsolin domain 2 and mutants involved in familial amyloidosis-Finnish type.

3. Mitogen-activated protein kinase phosphatase is required for genotoxic stress relief in Arabidopsis.

4. VASP protects actin filaments from gelsolin: an in vitro study with implications for platelet actin reorganizations.

5. Villin enhances hepatocyte growth factor-induced actin cytoskeleton remodeling in epithelial cells.

6. Adaptive differences in the structure and macromolecular compositions of the air and water corneas of the "four-eyed" fish (Anableps anableps).

7. Critical regulation of genes for tumor cell migration by AP-1.

8. NADPH oxidases regulate septin-mediated cytoskeletal remodeling during plant infection by the rice blast fungus.

9. Prognostic significance of gelsolin and MMP12 in Langerhans cell histiocytosis.

10. Steered molecular dynamics simulations on the "tail helix latch" hypothesis in the gelsolin activation process.