Literature DB >> 10025907

MLL-AF1q fusion resulting from t(1;11) in acute leukemia.

M Busson-Le Coniat1, F Salomon-Nguyen, J Hillion, O A Bernard, R Berger.   

Abstract

The MLL gene, located on chromosome band 11q23 is fused to different partner genes as a result of various chromosomal translocations in hematopoietic malignancies. A t(1;11) (q21;q23) resulting in a MLL-AF1q fusion gene has previously been reported. Cytogenetic studies on six cases are reported, including one three-way translocation. FISH analysis using a YAC encompassing the MLL gene and a YAC encompassing the AF1q locus showed splitting in three cases and two patients, respectively. PCR analysis of two cases confirmed that AF1q is specifically associated with t(1;11)(q21;q23). The MLL-AF1q fusion mRNA was similar to that previously described in one case and involved MLL exon 7 in the other. This study confirms the specific involvement of AF1q in t(1;11) (q21;q23)-positive acute leukemia with monocytic involvement.

Entities:  

Mesh：

Year:  1999        PMID： 10025907     DOI： 10.1038/sj.leu.2401299

Source DB:  PubMed          Journal:  Leukemia        ISSN： 0887-6924            Impact factor:   11.528


  7 in total

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2.  C/EBPbeta suppression by interruption of CUGBP1 resulting from a complex rearrangement of MLL.

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Journal:  Br J Cancer       Date:  2006-10-24       Impact factor: 7.640

4.  Involvement of AF1q/MLLT11 in the progression of ovarian cancer.

Authors:  Paola Tiberio; Ludmila Lozneanu; Valentina Angeloni; Elena Cavadini; Patrizia Pinciroli; Maurizio Callari; Maria Luisa Carcangiu; Domenica Lorusso; Francesco Raspagliesi; Valentina Pala; Maria Grazia Daidone; Valentina Appierto
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Journal:  Front Oncol       Date:  2022-08-12       Impact factor: 5.738

6.  Both SEPT2 and MLL are down-regulated in MLL-SEPT2 therapy-related myeloid neoplasia.

Authors:  Nuno Cerveira; Joana Santos; Susana Bizarro; Vera Costa; Franclim R Ribeiro; Susana Lisboa; Cecília Correia; Lurdes Torres; Joana Vieira; Simone Snijder; José M Mariz; Lucília Norton; Clemens H Mellink; Arjan Buijs; Manuel R Teixeira
Journal:  BMC Cancer       Date:  2009-05-15       Impact factor: 4.430

7.  RE1 silencing transcription factor (REST) negatively regulates ALL1-fused from chromosome 1q (AF1q) gene transcription.

Authors:  Yuanyuan Hu; Qianwen Sun; Chen Zhang; Qingquan Sha; Xiulian Sun
Journal:  BMC Mol Biol       Date:  2015-09-05       Impact factor: 2.946
  7 in total

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