| Literature DB >> 17854664 |
William T Choi1, Matthew R Folsom, Mohammed F Azim, Claus Meyer, Eric Kowarz, Rolf Marschalek, Nikolai A Timchenko, Rizwan C Naeem, Dean A Lee.
Abstract
Translocations involving the mixed-lineage leukemia gene (MLL) confer a poor prognosis in acute leukemias. In t(1;11)(q21;q23), MLL is fused reciprocally with AF1q. Here we describe a t(1;11)(q21;q23) with a secondary event involving insertion of the telomeric portion of MLL into the p arm of chromosome 11 (11p11). We show that this latter event interrupts the CUG triplet repeat binding protein-1 (CUGBP1) gene, a translational enhancer of C/EBPbeta. We then showed that these cells have reduced expression of CUGBP1 and C/EBPbeta when compared to other AML blasts. This is the first report to describe insertional disruption of the CUGBP1 gene and to suggest a role for the CUGBP1-C/EBPbeta pathway in leukemogenesis.Entities:
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Year: 2007 PMID： 17854664 PMCID： PMC3311538 DOI： 10.1016/j.cancergencyto.2007.07.002
Source DB: PubMed Journal: Cancer Genet Cytogenet ISSN： 0165-4608