UNLABELLED: The reproducibility of (+/-)-alpha-[11C] dihydrotetrabenazine (DTBZ) measures in PET was studied in 10 healthy human subjects, aged 22-76 y. METHODS: The scan-to-scan variation of several measures used in PET data analysis was determined, including the radioactivity ratio (target-to-reference), plasma-input Logan total distribution volume (DV), plasma-input Logan Bmax/Kd and tissue-input Logan Bmax/Kd values. RESULTS: The radioactivity ratios, plasma-input Bmax/Kd and tissue-input Bmax/Kd all have higher reliability than plasma-input total DV values. In addition, measures using the occipital cortex as the reference region have higher reliability than the same measures using the cerebellum as the reference region. CONCLUSION: Our results show that DTBZ is a reliable PET tracer that provides reproducible in vivo measurement of striatal vesicular monoamine transporter density. In the selection of reference regions for DTBZ PET data analysis, caution must be exercised in circumstances when DTBZ binding in the occipital cortex or the cerebellum may be altered.
UNLABELLED: The reproducibility of (+/-)-alpha-[11C] dihydrotetrabenazine (DTBZ) measures in PET was studied in 10 healthy human subjects, aged 22-76 y. METHODS: The scan-to-scan variation of several measures used in PET data analysis was determined, including the radioactivity ratio (target-to-reference), plasma-input Logan total distribution volume (DV), plasma-input Logan Bmax/Kd and tissue-input Logan Bmax/Kd values. RESULTS: The radioactivity ratios, plasma-input Bmax/Kd and tissue-input Bmax/Kd all have higher reliability than plasma-input total DV values. In addition, measures using the occipital cortex as the reference region have higher reliability than the same measures using the cerebellum as the reference region. CONCLUSION: Our results show that DTBZ is a reliable PET tracer that provides reproducible in vivo measurement of striatal vesicular monoamine transporter density. In the selection of reference regions for DTBZ PET data analysis, caution must be exercised in circumstances when DTBZ binding in the occipital cortex or the cerebellum may be altered.
Authors: Leigh Christopher; Connie Marras; Sarah Duff-Canning; Yuko Koshimori; Robert Chen; Isabelle Boileau; Barbara Segura; Oury Monchi; Anthony E Lang; Pablo Rusjan; Sylvain Houle; Antonio P Strafella Journal: Brain Date: 2013-12-12 Impact factor: 13.501
Authors: Rajesh Narendran; Brian J Lopresti; Diana Martinez; Neale Scott Mason; Michael Himes; Maureen A May; Dennis C Daley; Julie C Price; Chester A Mathis; W Gordon Frankle Journal: Am J Psychiatry Date: 2011-10-31 Impact factor: 18.112
Authors: Leigh Christopher; Sarah Duff-Canning; Yuko Koshimori; Barbara Segura; Isabelle Boileau; Robert Chen; Anthony E Lang; Sylvain Houle; Pablo Rusjan; Antonio P Strafella Journal: Ann Neurol Date: 2014-12-30 Impact factor: 10.422
Authors: Brad A Racette; Laura Good; Jo Ann Antenor; Lori McGee-Minnich; Stephen M Moerlein; Tom O Videen; Joel S Perlmutter Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2006-04-05 Impact factor: 3.568