Literature DB >> 10021943

Glycolipids from sponges. VII. Simplexides, novel immunosuppressive glycolipids from the Caribbean sponge Plakortis simplex.

V Costantino1, E Fattorusso, A Mangoni, M Di Rosa, A Ianaro.   

Abstract

The new glycolipids simplexides (1) have been isolated from the marine sponge Plakortis simplex, and their structure determined by spectroscopic data and microgram-scale chemical degradation. Simplexides are composed of long-chain secondary alcohols glycosylated by a disaccharide chain, and represent a new structural kind of glycolipids. Simplexides strongly inhibit proliferation of activated T-cells by a non-cytotoxic mechanism and can be regarded as simple model molecules for designing immunosuppressive drugs.

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Year:  1999        PMID： 10021943     DOI： 10.1016/s0960-894x(98)00719-7

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  13 in total

1.  Ieodoglucomide C and Ieodoglycolipid, New Glycolipids from a Marine-Derived Bacterium Bacillus licheniformis 09IDYM23.

Authors:  Fakir Shahidullah Tareq; Hyi-Seung Lee; Yeon-Ju Lee; Jong Seok Lee; Hee Jae Shin
Journal:  Lipids       Date:  2015-04-18       Impact factor: 1.880

Review 2.  Astonishing diversity of natural surfactants: 1. Glycosides of fatty acids and alcohols.

Authors:  Valery M Dembitsky
Journal:  Lipids       Date:  2004-10       Impact factor: 1.880

Review 3.  Glycosides from marine sponges (Porifera, Demospongiae): structures, taxonomical distribution, biological activities and biological roles.

Authors:  Vladimir I Kalinin; Natalia V Ivanchina; Vladimir B Krasokhin; Tatyana N Makarieva; Valentin A Stonik
Journal:  Mar Drugs       Date:  2012-08-10       Impact factor: 6.085

4.  Simplexide induces CD1d-dependent cytokine and chemokine production from human monocytes.

Authors:  Stefania Loffredo; Rosaria I Staiano; Francescopaolo Granata; Valeria Costantino; Francesco Borriello; Annunziata Frattini; Maria Teresa Lepore; Alfonso Mangoni; Gianni Marone; Massimo Triggiani
Journal:  PLoS One       Date:  2014-11-12       Impact factor: 3.240

5.  Polyketide synthases in the microbiome of the marine sponge Plakortis halichondrioides: a metagenomic update.

Authors:  Gerardo Della Sala; Thomas Hochmuth; Roberta Teta; Valeria Costantino; Alfonso Mangoni
Journal:  Mar Drugs       Date:  2014-11-14       Impact factor: 5.118

Review 6.  Marine Sponges as a Drug Treasure.

Authors:  Komal Anjum; Syed Qamar Abbas; Sayed Asmat Ali Shah; Najeeb Akhter; Sundas Batool; Syed Shams Ul Hassan
Journal:  Biomol Ther (Seoul)       Date:  2016-07-01       Impact factor: 4.634

Review 7.  Chemistry and Biology of Bioactive Glycolipids of Marine Origin.

Authors:  Iván Cheng-Sánchez; Francisco Sarabia
Journal:  Mar Drugs       Date:  2018-08-22       Impact factor: 5.118

8.  New constituents from the Korean sponge Plakortis simplex.

Authors:  Jung Soon Oh; Buyng Su Hwang; Ok-Hwa Kang; Dong-Yeul Kwon; Jung-Rae Rho
Journal:  Mar Drugs       Date:  2013-11-05       Impact factor: 5.118

9.  Zeamide, a Glycosylinositol Phosphorylceramide with the Novel Core Arap(1β→6)Ins Motif from the Marine Sponge Svenzea zeai.

Authors:  Gerardo Della Sala; Roberta Teta; Germana Esposito; Joseph R Pawlik; Alfonso Mangoni; Valeria Costantino
Journal:  Molecules       Date:  2017-09-01       Impact factor: 4.411

10.  Simplexidine, a 4-alkylpyridinium alkaloid from the Caribbean sponge Plakortis simplex.

Authors:  Ernesto Fattorusso; Adriana Romano; Fernando Scala; Orazio Taglialatela-Scafati
Journal:  Molecules       Date:  2008-07-17       Impact factor: 4.411
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