Literature DB >> 10021911

Substituted 7H-pyrido[4,3-c]carbazoles with potent anti-HIV activity.

K Hirata1, C Ito, H Furukawa, M Itoigawa, L M Cosentino, K H Lee.   

Abstract

Several substituted 7H-pyrido[4,3-c]carbazoles were synthesized from the natural product mukonal and tested for inhibition of HIV replication in H9 lymphocytes. 5-Methoxy-7-methyl-7H-pyrido[4,3-c]carbazole (7) had an EC50 value of 0.0054 microgram/mL and the highest therapeutic index (TI = 503) in the series.

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Year:  1999        PMID： 10021911     DOI： 10.1016/s0960-894x(98)00708-2

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  6-Meth-oxy-2,3,4,9-tetra-hydro-1H-carbazol-1-one.

Authors:  M Sridharan; K J Rajendra Prasad; A Thomas Gunaseelan; A Thiruvalluvar; A Linden
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-03-29

2.  Crystal structure of 3-(9H-carbazol-9-yl)-N'-[(E)-4-chloro-benzyl-idene]propano-hydrazide.

Authors:  Mehmet Akkurt; Jerry P Jasinski; Shaaban K Mohamed; Talaat I El-Emary; Mustafa R Albayati
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2015-11-14

3.  Carbazole Alkaloids from Clausena anisum-olens: Isolation, Characterization, and Anti-HIV Evaluation.

Authors:  Jing-Hua Yang; Xin-Yi Wang; Yi-Ping Zhou; Rong Lu; Chin-Ho Chen; Meng-Han Zhang; Yung-Yi Cheng; Susan L Morris-Natschke; Kuo-Hsiung Lee; Yun-Song Wang
Journal:  Molecules       Date:  2019-12-26       Impact factor: 4.411
  3 in total

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