Literature DB >> 9990477

In vitro activity of SCH 27899 (Ziracin) against Legionella species.

P H Edelstein1, M A Edelstein.   

Abstract

The activities of Sch 27899 (Ziracin), erythromycin, and ofloxacin against 102 Legionella spp. isolates were measured by a microbroth dilution method. The MICs that inhibited 90% of strains tested were 0.25, 0.5, and 0.06 microgram/mL for Sch 27899, erythromycin, and ofloxacin, respectively. The activity of Sch 27899 against intracellular Legionella pneumophila could not be determined because of complete inactivation of the drug by tissue culture medium components.

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Year:  1999        PMID： 9990477     DOI： 10.1016/s0732-8893(98)00106-0

Source DB:  PubMed          Journal:  Diagn Microbiol Infect Dis        ISSN： 0732-8893            Impact factor:   2.803


  4 in total

1.  Efficacy of SCH27899 in an animal model of Legionnaires' disease using immunocompromised A/J mice.

Authors:  J K Brieland; D Loebenberg; F Menzel; R S Hare
Journal:  Antimicrob Agents Chemother       Date:  2000-05       Impact factor: 5.191

2.  In vitro activity of ABT-773 against Legionella pneumophila, its pharmacokinetics in guinea pigs, and its use to treat guinea pigs with L. pneumophila pneumonia.

Authors:  P H Edelstein; F Higa; M A Edelstein
Journal:  Antimicrob Agents Chemother       Date:  2001-10       Impact factor: 5.191

3.  Evernimicin (SCH27899) inhibits both translation and 50S ribosomal subunit formation in Staphylococcus aureus cells.

Authors:  W S Champney; C L Tober
Journal:  Antimicrob Agents Chemother       Date:  2000-06       Impact factor: 5.191

Review 4.  Antimicrobial growth promoters used in animal feed: effects of less well known antibiotics on gram-positive bacteria.

Authors:  Patrick Butaye; Luc A Devriese; Freddy Haesebrouck
Journal:  Clin Microbiol Rev       Date:  2003-04       Impact factor: 26.132
  4 in total

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