Literature DB >> 9990463

2,6,9-trisubstituted purines: optimization towards highly potent and selective CDK1 inhibitors.

P Imbach1, H G Capraro, P Furet, H Mett, T Meyer, J Zimmermann.   

Abstract

Novel 2,6,9-substituted purine derivatives represent a class of potent and selective inhibitors of CDK1/cyclinB. The synthesis, SAR and biological profile of selected compounds are described.

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Year:  1999        PMID： 9990463     DOI： 10.1016/s0960-894x(98)00691-x

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  11 in total

1.  Optimization of High-Throughput Methyltransferase Assays for the Discovery of Small Molecule Inhibitors.

Authors:  Guangping Dong; Adam Yasgar; Darrell L Peterson; Alexey Zakharov; Daniel Talley; Ken Chih-Chien Cheng; Ajit Jadhav; Anton Simeonov; Rong Huang
Journal:  ACS Comb Sci       Date:  2020-06-27       Impact factor: 3.784

2.  Androgen receptor serine 81 phosphorylation mediates chromatin binding and transcriptional activation.

Authors:  Shaoyong Chen; Sarah Gulla; Changmeng Cai; Steven P Balk
Journal:  J Biol Chem       Date:  2012-01-24       Impact factor: 5.157

3.  A triple exon-skipping luciferase reporter assay identifies a new CLK inhibitor pharmacophore.

Authors:  Yihui Shi; Jaehyeon Park; Chandraiah Lagisetti; Wei Zhou; Lidia C Sambucetti; Thomas R Webb
Journal:  Bioorg Med Chem Lett       Date:  2016-12-24       Impact factor: 2.823

4.  Identification of cylin-dependent kinase 1 inhibitors of a new chemical type by structure-based design and database searching.

Authors:  P Furet; T Meyer; P Mittl; H Fretz
Journal:  J Comput Aided Mol Des       Date:  2001-05       Impact factor: 3.686

5.  CDK1 differentially regulates G-overhang generation at leading- and lagging-strand telomeres in telomerase-negative cells in G2 phase.

Authors:  Xueyu Dai; Chenhui Huang; Weihang Chai
Journal:  Cell Cycle       Date:  2012-08-08       Impact factor: 4.534

6.  CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells.

Authors:  Yongkun Wei; Ya-Huey Chen; Long-Yuan Li; Jingyu Lang; Su-Peng Yeh; Bin Shi; Cheng-Chieh Yang; Jer-Yen Yang; Chun-Yi Lin; Chien-Chen Lai; Mien-Chie Hung
Journal:  Nat Cell Biol       Date:  2010-12-05       Impact factor: 28.824

7.  Role of a DNA damage checkpoint pathway in ionizing radiation-induced glioblastoma cell migration and invasion.

Authors:  Issai Vanan; Zhiwan Dong; Elena Tosti; Gregg Warshaw; Marc Symons; Rosamaria Ruggieri
Journal:  Cell Mol Neurobiol       Date:  2012-05-03       Impact factor: 5.046

8.  Structure-based design of potent CDK1 inhibitors derived from olomoucine.

Authors:  P Furet; J Zimmermann; H G Capraro; T Meyer; P Imbach
Journal:  J Comput Aided Mol Des       Date:  2000-07       Impact factor: 3.686

9.  Dynamic regulation of the PR-Set7 histone methyltransferase is required for normal cell cycle progression.

Authors:  Shumin Wu; Weiping Wang; Xiangduo Kong; Lauren M Congdon; Kyoko Yokomori; Marc W Kirschner; Judd C Rice
Journal:  Genes Dev       Date:  2010-10-21       Impact factor: 11.361

10.  Global changes in and characterization of specific sites of phosphorylation in mouse and human histone H1 Isoforms upon CDK inhibitor treatment using mass spectrometry.

Authors:  Leesa J Deterding; Maureen K Bunger; Geoffrey C Banks; Kenneth B Tomer; Trevor K Archer
Journal:  J Proteome Res       Date:  2008-04-17       Impact factor: 5.370
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