Literature DB >> 9990036

Catalytic subunit of DNA-dependent protein kinase: impact on lymphocyte development and tumorigenesis.

A Kurimasa1, H Ouyang, L J Dong, S Wang, X Li, C Cordon-Cardo, D J Chen, G C Li.   

Abstract

The DNA-dependent protein kinase (DNA-PK) consists of a heterodimer DNA-binding complex, Ku70 and Ku80, and a large catalytic subunit, DNA-PKcs. To examine the role of DNA-PKcs in lymphocyte development, radiation sensitivity, and tumorigenesis, we disrupted the mouse DNA-PKcs by homologous recombination. DNA-PKcs-null mice exhibit neither growth retardation nor a high frequency of T cell lymphoma development, but show severe immunodeficiency and radiation hypersensitivity. In contrast to the Ku70-/- and Ku80-/- phenotype, DNA-PKcs-null mice are blocked for V(D)J coding but not for signal-end joint formation. Furthermore, inactivation of DNA-PKcs leads to hyperplasia and dysplasia of the intestinal mucosa and production of aberrant crypt foci, suggesting a novel role of DNA-PKcs in tumor suppression.

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Year:  1999        PMID： 9990036      PMCID： PMC15475          DOI： 10.1073/pnas.96.4.1403

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  32 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  1994-07-19       Impact factor: 11.205

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6.  DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect.

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Journal:  Science       Date:  1995-02-24       Impact factor: 47.728

7.  Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA double-strand-break-repair mutant mammalian cells.

Authors:  S R Peterson; A Kurimasa; M Oshimura; W S Dynan; E M Bradbury; D J Chen
Journal:  Proc Natl Acad Sci U S A       Date:  1995-04-11       Impact factor: 11.205

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Journal:  Proc Natl Acad Sci U S A       Date:  1994-08-30       Impact factor: 11.205

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Authors:  T Blunt; N J Finnie; G E Taccioli; G C Smith; J Demengeot; T M Gottlieb; R Mizuta; A J Varghese; F W Alt; P A Jeggo; S P Jackson
Journal:  Cell       Date:  1995-03-10       Impact factor: 41.582
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  76 in total

1.  The catalytic subunit of DNA-dependent protein kinase selectively regulates p53-dependent apoptosis but not cell-cycle arrest.

Authors:  S Wang; M Guo; H Ouyang; X Li; C Cordon-Cardo; A Kurimasa; D J Chen; Z Fuks; C C Ling; G C Li
Journal:  Proc Natl Acad Sci U S A       Date:  2000-02-15       Impact factor: 11.205

2.  A small interfering RNA screen of genes involved in DNA repair identifies tumor-specific radiosensitization by POLQ knockdown.

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Review 4.  DNA-damage repair; the good, the bad, and the ugly.

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Review 5.  DNA damage and repair during lymphoid development: antigen receptor diversity, genomic integrity and lymphomagenesis.

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Journal:  Immunol Res       Date:  2008       Impact factor: 2.829

6.  Response to multiple radiation doses of fibroblasts over-expressing dominant negative Ku70.

Authors:  Muneyasu Urano; Yunhong Huang; Fuqiu He; Akiko Minami; C Clifton Ling; Gloria C Li
Journal:  Int J Radiat Oncol Biol Phys       Date:  2008-04-18       Impact factor: 7.038

7.  Prognostic significance of ataxia-telangiectasia mutated, DNA-dependent protein kinase catalytic subunit, and Ku heterodimeric regulatory complex 86-kD subunit expression in patients with nonsmall cell lung cancer.

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8.  Loss of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) expression in gastric cancers.

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10.  Characteristics of DNA-binding proteins determine the biological sensitivity to high-linear energy transfer radiation.

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