Literature DB >> 9989602

HIV-1 gp160 decreases the K+ voltage-gated current from Jurkat E6.1 T cells by up-phosphorylation.

O Dellis1, F Bouteau, M Guenounou, J P Rona.   

Abstract

HIV-1 gp120/gp160 is known to disturb the activity of p56lck, protein kinase C (PKC) and Ca2+ homeostasis in T lymphocytes. We found that gp160 decreases the Kv1.3 current of Jurkat E6.1 cells probably by increasing the PKC-dependent phosphorylation of Kv channel protein after 5 days. This decrease is dose-dependent. In contrast, gp160 did not decrease the Kv1.3 current of the JCaM1.6 cell line, a p56(lck)-defective Jurkat cell line. This shows that p56lck was at the beginning of the events which induced the Kv1.3 current decrease. As a consequence of this decrease, Jurkat E6.1 cells were depolarized and exhibited a volume increase.

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Year:  1999        PMID： 9989602     DOI： 10.1016/s0014-5793(98)01691-3

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  4 in total

1.  Modulation of Kv1.3 channels by protein kinase A I in T lymphocytes is mediated by the disc large 1-tyrosine kinase Lck complex.

Authors:  Zerrin Kuras; Vladimir Kucher; Scott M Gordon; Lisa Neumeier; Ameet A Chimote; Alexandra H Filipovich; Laura Conforti
Journal:  Am J Physiol Cell Physiol       Date:  2012-02-29       Impact factor: 4.249

2.  Signalling during hypoxia in human T lymphocytes--critical role of the src protein tyrosine kinase p56Lck in the O2 sensitivity of Kv1.3 channels.

Authors:  Peter Szigligeti; Lisa Neumeier; Eugene Duke; Claire Chougnet; Koichi Takimoto; Susan Molleran Lee; Alexandra H Filipovich; Laura Conforti
Journal:  J Physiol       Date:  2006-04-06       Impact factor: 5.182

Review 3.  Co-receptor signaling in the pathogenesis of neuroHIV.

Authors:  E A Nickoloff-Bybel; L Festa; O Meucci; P J Gaskill
Journal:  Retrovirology       Date:  2021-08-24       Impact factor: 4.602

4.  Differential Activity of Voltage- and Ca2+-Dependent Potassium Channels in Leukemic T Cell Lines: Jurkat Cells Represent an Exceptional Case.

Authors:  Salvador Valle-Reyes; Georgina Valencia-Cruz; Liliana Liñan-Rico; Igor Pottosin; Oxana Dobrovinskaya
Journal:  Front Physiol       Date:  2018-05-09       Impact factor: 4.566
  4 in total

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