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Literature DB >> 9988265

Late onset of renal and hepatic cysts in Pkd1-targeted heterozygotes.

W Lu, X Fan, N Basora, H Babakhanlou, T Law, N Rifai, P C Harris, A R Perez-Atayde, H G Rennke, J Zhou.

Abstract

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1999 PMID： 9988265 DOI： 10.1038/5944

Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330

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48 in total

Review 1. Polycystic kidney disease: In danger of being X-rated?

Authors: J J Grantham; J P Calvet
Journal: Proc Natl Acad Sci U S A Date: 2001-01-30 Impact factor: 11.205

2. MAP/ERK kinase kinase 1 (MEKK1) mediates transcriptional repression by interacting with polycystic kidney disease-1 (PKD1) promoter-bound p53 tumor suppressor protein.

Authors: M Rafiq Islam; Tamara Jimenez; Christopher Pelham; Marianna Rodova; Sanjeev Puri; Brenda S Magenheimer; Robin L Maser; Christian Widmann; James P Calvet
Journal: J Biol Chem Date: 2010-10-05 Impact factor: 5.157

3. Loss of PKD1 and loss of Bcl-2 elicit polycystic kidney disease through distinct mechanisms.

Authors: P Hughes; M Robati; W Lu; J Zhou; A Strasser; P Bouillet
Journal: Cell Death Differ Date: 2005-11-11 Impact factor: 15.828

Review 4. Calcium at fertilization and in early development.

Authors: Michael Whitaker
Journal: Physiol Rev Date: 2006-01 Impact factor: 37.312

5. Patient-iPSC-Derived Kidney Organoids Show Functional Validation of a Ciliopathic Renal Phenotype and Reveal Underlying Pathogenetic Mechanisms.

Authors: Thomas A Forbes; Sara E Howden; Kynan Lawlor; Belinda Phipson; Jovana Maksimovic; Lorna Hale; Sean Wilson; Catherine Quinlan; Gladys Ho; Katherine Holman; Bruce Bennetts; Joanna Crawford; Peter Trnka; Alicia Oshlack; Chirag Patel; Andrew Mallett; Cas Simons; Melissa H Little
Journal: Am J Hum Genet Date: 2018-04-26 Impact factor: 11.025

6. A mouse model of osteochondromagenesis from clonal inactivation of Ext1 in chondrocytes.

Authors: Kevin B Jones; Virginia Piombo; Charles Searby; Gail Kurriger; Baoli Yang; Florian Grabellus; Peter J Roughley; Jose A Morcuende; Joseph A Buckwalter; Mario R Capecchi; Andrea Vortkamp; Val C Sheffield
Journal: Proc Natl Acad Sci U S A Date: 2009-12-22 Impact factor: 11.205

Late onset of renal and hepatic cysts in Pkd1-targeted heterozygotes.

Review 1. Polycystic kidney disease: In danger of being X-rated?

2. MAP/ERK kinase kinase 1 (MEKK1) mediates transcriptional repression by interacting with polycystic kidney disease-1 (PKD1) promoter-bound p53 tumor suppressor protein.

3. Loss of PKD1 and loss of Bcl-2 elicit polycystic kidney disease through distinct mechanisms.

Review 4. Calcium at fertilization and in early development.

5. Patient-iPSC-Derived Kidney Organoids Show Functional Validation of a Ciliopathic Renal Phenotype and Reveal Underlying Pathogenetic Mechanisms.

6. A mouse model of osteochondromagenesis from clonal inactivation of Ext1 in chondrocytes.

7. Pkd1 transgenic mice: adult model of polycystic kidney disease with extrarenal and renal phenotypes.

8. Src inhibition ameliorates polycystic kidney disease.

9. Functional polycystin-1 dosage governs autosomal dominant polycystic kidney disease severity.

10. Pkd1 haploinsufficiency increases renal damage and induces microcyst formation following ischemia/reperfusion.