Literature DB >> 9986788

Transmission of human immunodeficiency type 1 viruses with intersubtype recombinant long terminal repeat sequences.

J T Blackard1, B R Renjifo, D Mwakagile, M A Montano, W W Fawzi, M Essex.   

Abstract

Retroviruses such as human immunodeficiency virus type 1 (HIV-1) contain two RNA strands per virion, and recombination can occur frequently during reverse transcription. Recombination may occur between HIV-1 genomes of the same subtype or among genomes of two or more distinct subtypes present in an individual. In the current study, we found that recombinatorial events were not limited to viral structural genes such as gag and env, but rather, recombination could likewise occur within the 5' long terminal repeat (LTR). Intersubtype recombinant LTRs among HIV-1 subtypes A, C, and D were found in Tanzanian infants. By introducing novel LTR sequences, these recombinant LTR viruses may further increase the adaptive potential and fitness of HIV-1. Copyright 1999 Academic Press.

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Year:  1999        PMID： 9986788     DOI： 10.1006/viro.1998.9504

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  9 in total

1.  Persistence of pathogenic challenge virus in macaques protected by simian immunodeficiency virus SIVmacDeltanef.

Authors:  E Khatissian; V Monceaux; M C Cumont; M P Kieny; A M Aubertin; B Hurtrel
Journal:  J Virol       Date:  2001-02       Impact factor: 5.103

2.  High rate of recombination throughout the human immunodeficiency virus type 1 genome.

Authors:  A E Jetzt; H Yu; G J Klarmann; Y Ron; B D Preston; J P Dougherty
Journal:  J Virol       Date:  2000-02       Impact factor: 5.103

3.  Characterisation of the long terminal repeat regions of South African human immunodeficiency virus type 1 isolates.

Authors:  G M Hunt; D Johnson; C T Tiemesse
Journal:  Virus Genes       Date:  2001       Impact factor: 2.332

4.  Construction and analysis of an infectious human Immunodeficiency virus type 1 subtype C molecular clone.

Authors:  T Ndung'u; B Renjifo; M Essex
Journal:  J Virol       Date:  2001-06       Impact factor: 5.103

5.  HIV-1 clade promoters strongly influence spatial and temporal dynamics of viral replication in vivo.

Authors:  Mireille Centlivre; Peter Sommer; Marie Michel; Raphaël Ho Tsong Fang; Sandrine Gofflo; Jenny Valladeau; Nathalie Schmitt; Françoise Thierry; Bruno Hurtrel; Simon Wain-Hobson; Monica Sala
Journal:  J Clin Invest       Date:  2005-02       Impact factor: 14.808

6.  Revisiting the recombinant history of HIV-1 group M with dynamic network community detection.

Authors:  Abayomi S Olabode; Garway T Ng; Kaitlyn E Wade; Mikhail Salnikov; Heather E Grant; David W Dick; Art F Y Poon
Journal:  Proc Natl Acad Sci U S A       Date:  2022-05-02       Impact factor: 12.779

7.  In vitro intersubtype recombinants of human immunodeficiency virus type 1: comparison to recent and circulating in vivo recombinant forms.

Authors:  Miguel E Quiñones-Mateu; Yong Gao; Sarah C Ball; Andre J Marozsan; Awet Abraha; Eric J Arts
Journal:  J Virol       Date:  2002-10       Impact factor: 5.103

8.  Highly significant antiviral activity of HIV-1 LTR-specific tre-recombinase in humanized mice.

Authors:  Ilona Hauber; Helga Hofmann-Sieber; Jan Chemnitz; Danilo Dubrau; Janet Chusainow; Rolf Stucka; Philip Hartjen; Axel Schambach; Patrick Ziegler; Karl Hackmann; Evelin Schröck; Udo Schumacher; Christoph Lindner; Adam Grundhoff; Christopher Baum; Markus G Manz; Frank Buchholz; Joachim Hauber
Journal:  PLoS Pathog       Date:  2013-09-26       Impact factor: 6.823

9.  Excision of HIV-1 proviral DNA by recombinant cell permeable tre-recombinase.

Authors:  Lakshmikanth Mariyanna; Poornima Priyadarshini; Helga Hofmann-Sieber; Marcel Krepstakies; Nicole Walz; Adam Grundhoff; Frank Buchholz; Eberhard Hildt; Joachim Hauber
Journal:  PLoS One       Date:  2012-02-13       Impact factor: 3.240
  9 in total

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