Literature DB >> 998278

On the formation and effects of thromboxane A2 in human platelets.

J Svensson, M Hamberg, B Samuelsson.   

Abstract

Incubation of arachidonic acid and prostaglandin G2 with a suspension of human platelets led to formation of an unstable (t1/2, 41+/-7 s) compound, thromboxane A2. Thromboxane A2 induced irreversible aggregation of washed platelets and of platelets in platelet-rich plasma and caused release of serotonin and ADP from platelets in platelet-rich plasma.

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Year:  1976        PMID： 998278     DOI： 10.1111/j.1748-1716.1976.tb10313.x

Source DB:  PubMed          Journal:  Acta Physiol Scand        ISSN： 0001-6772


  17 in total

Review 1.  Are phospholipases involved in platelet activation?

Authors:  G Bereziat
Journal:  Agents Actions       Date:  1979-10

2.  Functional role of thromboxane production by acutely rejecting renal allografts in rats.

Authors:  T M Coffman; W E Yarger; P E Klotman
Journal:  J Clin Invest       Date:  1985-04       Impact factor: 14.808

Review 3.  Introduction: thromboxane in biological systems and the possible impact of its inhibition.

Authors:  M Verstraete
Journal:  Br J Clin Pharmacol       Date:  1983       Impact factor: 4.335

Review 4.  The prostanoids in hemostasis and thrombosis: a review.

Authors:  J B Smith
Journal:  Am J Pathol       Date:  1980-06       Impact factor: 4.307

5.  Thrombosis: its role and prevention in cardiovascular events--Part I. Concepts of thrombogenesis and its prevention.

Authors:  L A Harker
Journal:  West J Med       Date:  1981-03

Review 6.  Advances in Our Understanding of Oxylipins Derived from Dietary PUFAs.

Authors:  Melissa Gabbs; Shan Leng; Jessay G Devassy; Md Monirujjaman; Harold M Aukema
Journal:  Adv Nutr       Date:  2015-09-15       Impact factor: 8.701

7.  Characterization of prostanoid relaxant/inhibitory receptors (psi) using a highly selective agonist, TR4979.

Authors:  P J Gardiner
Journal:  Br J Pharmacol       Date:  1986-01       Impact factor: 8.739

8.  Studies on L-640,035: a novel antagonist of contractile prostanoids in the lung.

Authors:  R Carrier; E J Cragoe; D Ethier; A W Ford-Hutchinson; Y Girard; R A Hall; P Hamel; J Rokach; N N Share; C A Stone
Journal:  Br J Pharmacol       Date:  1984-06       Impact factor: 8.739

9.  Binding of a radioiodinated 13-azapinane thromboxane antagonist to platelets: correlation with antiaggregatory activity in different species.

Authors:  S Narumiya; M Okuma; F Ushikubi
Journal:  Br J Pharmacol       Date:  1986-06       Impact factor: 8.739

10.  Antagonism of the thromboxane-sensitive contractile systems of the rabbit aorta, dog saphenous vein and guinea-pig trachea.

Authors:  R L Jones; V Peesapati; N H Wilson
Journal:  Br J Pharmacol       Date:  1982-07       Impact factor: 8.739
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