| Literature DB >> 9973234 |
M S Santos1, E M Pereira, A P Carvaho.
Abstract
The effect of glucose on the release of immunoreactive insulin (IRI) in synaptosomes isolated from rat brain was studied. In the absence of glucose synaptosomes release about 4% (0.77 microIU/mg protein) of total content. Glucose increases significantly the IRI released by synaptosomes. Addition of the glycolytic inhibitor iodoacetic acid (IAA), decreased the glucose-induced release of IRI by about 50%, suggesting that glucose metabolism is involved. The observation that glucose provides a concentration related signal for IRI release indicates that this synaptosomal preparation may be useful as a model for research on the mechanism of insulin release in brain.Entities:
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Year: 1999 PMID： 9973234 DOI： 10.1023/a:1020971812098
Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996