Pharmacokinetic curve fitting using numerical inverse Laplace transformation.

The combination of the nonlinear regression program ADAPT II with Talbot's method of numerical Laplace transformation, that allows parameter estimation when the model function is given only in the Laplace domain, is described and successfully applied to pharmacokinetic problems. The accuracy and precision of the method has been found satisfactory; its performance is comparable to that achieved in parameter estimation based on functions defined in the time domain.