Literature DB >> 99672

Increase of liver microsomal benzo(a)pyrene monooxygenase activity by subsequent glucuronidation.

K W Bock.   

Abstract

Benzo(a)pyrene monooxygenase activity in rat and guinea pig liver microsomes is markedly stimulated when UDP-glucuronic acid is present in the assay. This effect is further enhanced by addition of UDP-N-acetylglucosamine, an allosteric activator of UDP-glucuronyltransferase. The results suggest a coupling between microsomal monooxygenase and UDP-glucuronyltransferase which may assist elimination of toxic compounds.

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Year:  1978        PMID： 99672     DOI： 10.1007/bf00501380

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  12 in total

1.  A reliable, sensitive, and convenient radioactive assay for benzpyrene monooxygenase.

Authors:  J W DePierre; M S Moron; K A Johannesen; L Ernster
Journal:  Anal Biochem       Date:  1975-02       Impact factor: 3.365

2.  Alterations in tissue levels of uridine diphosphate glucose dehydrogenase, uridine diphosphate glucuronic acid pyrophosphatase and glucuronyl transferase induced by substances influencing the production of ascorbic acid.

Authors:  S HOLLMANN; O TOUSTER
Journal:  Biochim Biophys Acta       Date:  1962-08-13

3.  Kinetic properties of microsomal UDP-glucuronyltransferase. Evidence for cooperative kinetics and activation by UDP-N-acetylglucosamine.

Authors:  D A Vessey; J Goldenberg; D Zakim
Journal:  Biochim Biophys Acta       Date:  1973-05-05

4.  Conversion of naphthalene to trans-naphthalene dihydrodiol: evidence for the presence of a coupled aryl monooxygenase-epoxide hydrase system in hepatic microsomes.

Authors:  F Oesch; J Daly
Journal:  Biochem Biophys Res Commun       Date:  1972-02-25       Impact factor: 3.575

5.  Hydroxylation and subsequent glucuronide conjugation of desmethylimipramine in rat liver microsomes.

Authors:  C von Bahr; L Bertilsson
Journal:  Xenobiotica       Date:  1971-05       Impact factor: 1.908

6.  Studies on the activation in vitro of glucuronyltransferase.

Authors:  A Winsnes
Journal:  Biochim Biophys Acta       Date:  1969-11-04

7.  Radioactive assay for aryl hydrocarbon hydroxylase. Improved method and biological importance.

Authors:  J Van Cantfort; J De Graeve; J E Gielen
Journal:  Biochem Biophys Res Commun       Date:  1977-11-21       Impact factor: 3.575

8.  Metabolism of naphthalene to naphthalene dihydrodiol glucuronide in isolated hepatocytes and in liver microsomes.

Authors:  K W Bock; G van Ackeren; F Lorch; F W Birke
Journal:  Biochem Pharmacol       Date:  1976-11-01       Impact factor: 5.858

9.  UDP-glucuronyltransferase in perfused rat liver and in microsomes: influence of phenobarbital and 3-methylcholanthrene.

Authors:  K W Bock; I N White
Journal:  Eur J Biochem       Date:  1974-08-01

10.  The metabolism of benzo[a]pyrene by rat-liver homogenates.

Authors:  P Sims
Journal:  Biochem Pharmacol       Date:  1967-04       Impact factor: 5.858
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  1 in total

1.  Inhibition of diazepam metabolism in microsomal- and perfused liver preparations of the rat by desmethyldiazepam, N-methyloxazepam and oxazepam.

Authors:  E M Savenije-Chapel; A Bast; J Noordhoek
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1985 Jan-Mar       Impact factor: 2.441
  1 in total

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