Literature DB >> 996547

Hypoxanthine-guanine phosphoribosyltransferase mutant glioma cells: diminished monamine oxidase activity.

S D Skaper, J E Seegmiller.   

Abstract

A defective capability of cultured rat glioma cells to reutilize purine bases (hypoxanthine-guanine phosphoribosyltransferase deficiency) was associated with a reduced capacity to oxidatively deaminate serotonin and tryptamine. The mutant glioma cells were also more sensitive to the cytotoxic effects of serotonin than were normal cells

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Year:  1976        PMID： 996547     DOI： 10.1126/science.996547

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  4 in total

Review 1.  Heberden oration 1979: human aberrations of purine metabolism and their significance for rheumatology.

Authors:  J E Seegmiller
Journal:  Ann Rheum Dis       Date:  1980-04       Impact factor: 19.103

2.  Monoamino oxidase activity reduced in cultured human fetal cells deficient in hypoxanthine-guanine phosphoribosyltransferase activity.

Authors:  S D Skaper; I A Schafer
Journal:  Biochem Genet       Date:  1978-12       Impact factor: 1.890

3.  Properties of monoamine oxidase in control and Lesch-Nyhan fibroblasts.

Authors:  M R Castro Costa; S B Edelstein; C M Castiglione; H Chao; X O Breakefield
Journal:  Biochem Genet       Date:  1980-06       Impact factor: 1.890

4.  Consequences of impaired purine recycling in dopaminergic neurons.

Authors:  J C Lewers; I Ceballos-Picot; T L Shirley; L Mockel; K Egami; H A Jinnah
Journal:  Neuroscience       Date:  2008-01-17       Impact factor: 3.590
  4 in total

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