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Literature DB >> 995654

Induction of interferon by polyribonucleotides containing thiopyrimidines.

Abstract

The influence of thioketo substitution in pyrimidine bases of double-stranded polynucleotides on interferon induction was investigated. The stabilizing effect of 2-thioketo substitution was reflected in the increased interferon inducing activity of poly(A-s2U) over that of poly(A-U). Poly(A-s2U) and poly(I)-poly(s2C) were as effective as poly(I)-Poly(C) in rabbit cells. Poly(I)-poly(C) and poly(I)-poly(s2C) were compared in several animal species. No differences in biological effects were observed in rabbits and dogs. In rodents, poly(I)-poly(s2C) was less effective and less toxic.Poly(I)-poly(s2C) was highly resistant against degradation by human serum. Further investigations seem to be justified to elucidate whether this property offers any advantages for the potential clinical utilization of poly(I)-poly(s2C).

Entities: Chemical Species

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Year: 1976 PMID： 995654 PMCID： PMC343133 DOI： 10.1093/nar/3.10.2861

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

24 in total

1. Synthesis and properties of poly-2,4-dithiouridylic acid, a new analog of poly uridylic acid.

Authors: P Faerber; K H. Scheit
Journal: FEBS Lett Date: 1970-11-09 Impact factor: 4.124

2. Biological studies of interferon. I. Suppression of cellular infection with eastern equine encephalomyelitis virus.

Authors: R R WAGNER
Journal: Virology Date: 1961-03 Impact factor: 3.616

3. An integrated and comparative study of the antiviral effects and other biological properties of the polyinosinic acid-polycytidylic acid and its mismatched analogues.

Authors: P O Ts'o; J L Alderfer; J Levy; L W Marshall; J O'Malley; J S Horoszewicz; W A Carter
Journal: Mol Pharmacol Date: 1976-03 Impact factor: 4.436

4. Effect of pyrimidine and ribose modifications on the antiviral activity of synthetic polynucleotides.

Authors: P F Torrence; J A Waters; C E Buckler; B Witkop
Journal: Biochem Biophys Res Commun Date: 1973-06-08 Impact factor: 3.575

5. Thermal activation of the antiviral activity of synthetic polyribonucleotides: influence of DEAE-dextran in various cell cultures.

Authors: E De Clercq
Journal: J Gen Virol Date: 1971-02 Impact factor: 3.891

6. Induction of the interferon mechanism by single-stranded RNA: potentiation by polybasic substances.

Authors: A Billiau; C E Buckler; F Dianzani; C Uhlendorf; S Baron
Journal: Proc Soc Exp Biol Med Date: 1969-11

7. Requirement of a stable secondary structure for the antiviral activity of polynucleotides.

Authors: E De Clercq; T C Merigan
Journal: Nature Date: 1969-06-21 Impact factor: 49.962

8. The effects of thioketo substitution upon uracil-adenine interactions in polyribonucleotides. Synthesis and properties of the alternating polynucleotides poly(r(A-s2U)) and poly(r(A-s2s4U)).

Authors: K H Scheit; P Faerber
Journal: Eur J Biochem Date: 1975-01-15

9. The effects of thioketo substitution upon uracil-adenine interactions in polyribonucleotides. Synthesis and properties of poly (2-thiouridylic acid) and poly(2,4-dithiouridylic acid).

Authors: W Bähr; P Faerber; K H Scheit
Journal: Eur J Biochem Date: 1973-03-15

10. Mechanism of the antiviral activity resulting from sequential administration of complementary homopolyribonucleotides to cell cultures.

Authors: E De Clercq; P De Somer
Journal: J Virol Date: 1972-05 Impact factor: 5.103

3 in total