Literature DB >> 9952226

Effect of 5-fluorouracil on gastrointestinal carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in rats.

Y Seto1, H Nagawa, M Mori, T Tsuruo, T Muto.   

Abstract

This study was undertaken to determine the effect of 5-fluorouracil on gastrointestinal carcinogenesis. Sixty rats were divided into three groups of 20 rats each. All rats were exposed to N-methyl-N'-nitro-N-nitrosoguanidine for the first 20 weeks. Group 1 rats received intraperitoneal injections of 5-fluorouracil for the first 20 weeks and were then observed for the second 20 weeks. Group 2 rats also received 5-fluorouracil injections, but for the second 20 weeks. Group 3 rats received no 5-fluorouracil treatment. Four of 20 rats in group 1 developed an invasive adenocarcinoma. In group 3, invasive squamous cell carcinoma and adenocarcinoma developed in one rat each. None of the group 2 rats had malignant lesions. These results suggested that 5-fluorouracil is not effective in suppressing the initial stage of gastrointestinal carcinogenesis with a coexisting carcinogen. Rather, the therapeutic effect is exerted in later stages of tumor progression.

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Year:  1999        PMID： 9952226     DOI： 10.1023/a:1026650000008

Source DB:  PubMed          Journal:  Dig Dis Sci        ISSN： 0163-2116            Impact factor:   3.199


  22 in total

1.  Fluorinated pyrimidines, a new class of tumour-inhibitory compounds.

Authors:  C HEIDELBERGER; N K CHAUDHURI; P DANNEBERG; D MOOREN; L GRIESBACH; R DUSCHINSKY; R J SCHNITZER; E PLEVEN; J SCHEINER
Journal:  Nature       Date:  1957-03-30       Impact factor: 49.962

2.  Inhibition of murine subcutaneous and intravenous benzo(rst)pentaphene. Carcinogenesis by sweet orange oils and d-limonene.

Authors:  F Homburger; A Treger; E Boger
Journal:  Oncology       Date:  1971       Impact factor: 2.935

3.  DNA methylation in rat stomach and duodenum following chronic exposure to N-methyl-N'-nitro-N-nitrosoguanidine and the effect of dietary taurocholate.

Authors:  O Kobori; I Schmerold; B Ludeke; H Ohgaki; P Kleihues
Journal:  Carcinogenesis       Date:  1988-12       Impact factor: 4.944

4.  Acute leukemia after alkylating-agent therapy of ovarian cancer.

Authors:  R R Reimer; R Hoover; J F Fraumeni; R C Young
Journal:  N Engl J Med       Date:  1977-07-28       Impact factor: 91.245

5.  Effect of 1-hexylcarbamoyl-5-fluorouracil on development of rat urinary bladder tumor induced by N-butyl-N-(4-hydroxybutyl)nitrosamine.

Authors:  S Ozono; H Iwata; K Tsunemi; S Takahashi; H Matsuki; K Sasaki; Y Hirao; E Okajima
Journal:  Jpn J Exp Med       Date:  1988-06

6.  Leukemia following chemotherapy for breast cancer.

Authors:  R E Curtis; J D Boice; W C Moloney; L G Ries; J T Flannery
Journal:  Cancer Res       Date:  1990-05-01       Impact factor: 12.701

7.  Tests for chemical carcinogens. Report on the activity of derivatives of aromatic amines, nitrosamines, quinolines, nitroalkanes, amides, epoxides, aziridines, and purine antimetabolites.

Authors:  Z Hadidian; T N Fredrickson; E K Weisburger; J H Weisburger; R M Glass; N Mantel
Journal:  J Natl Cancer Inst       Date:  1968-10       Impact factor: 13.506

8.  5-Fluorouracil carcinogenesis in BALB/c mice.

Authors:  A Cavaliere; P F Alberti; R Vitali
Journal:  Tumori       Date:  1990-04-30

9.  Gastro-intestinal tumours in rats and mice following various routes of administration of N-methyl-N-nitroso-N'-nitroguanidine and N-ethyl-N-nitroso-N'-nitroguanidine.

Authors:  R Schoental; J P Bensted
Journal:  Br J Cancer       Date:  1969-12       Impact factor: 7.640

10.  Risk of leukaemia in ovarian tumour and breast cancer patients following treatment by cyclophosphamide.

Authors:  J F Haas; B Kittelmann; W H Mehnert; W Staneczek; M Möhner; J M Kaldor; N E Day
Journal:  Br J Cancer       Date:  1987-02       Impact factor: 7.640
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